BAKER BROS. ADVISORS LP

Director · Other reporting person · Ten-percent owner · REPL, CELC, INCY, KOD, VTVT, KYMR …

As of 2026-09-16, BAKER BROS. ADVISORS LP has 301 Form 4 transactions on record across 18 companies — 77 in the trailing 12 months.

Everything this person has disclosed to the SEC on Form 4 — across every company they file for — reconstructed from the public record. A filing history, not a tip sheet.

Pattern in the record: open-market purchases filed in August in multiple years since 2025 — a recurring calendar cadence, more consistent with scheduled activity than a one-off decision.

Reconstructed holdings

Direct: $0Indirect: $5.9B$5.9Bas of 2026-09-16
  • Direct $0
  • Indirect $5.9B
INCYindirect28,205,760 sh$3.5B
BGNEindirect8,740,387 sh$1.6B
CELCindirect4,372,852 sh$361.1M
DBVTindirect25,005,240 sh$294.8M
ONCindirect161,550 sh$56.2M
REPLindirect2,609,946 sh$33.8M
TRDAindirect4,691,392 sh$32.3M
KNSAindirect36,474 sh$2.8M
ACADindirect32,008 sh$882K
IMCRindirect26,198 sh$828K

Reconstructed from this person's own Form 4 filings — the total each filing reported owning afterward, priced at the close on the as-of date shown. A filed position can lag the real one.

Direct and indirect holdings (e.g. through a trust or fund) are tagged separately, as filed.

Trades by company

MDGL · 60 trades
2026-06-17: Award / grant, 908 sh ($0)2026-06-17: Award / grant, 1,532 sh ($0)2026-06-17: Award / grant, 908 sh ($0)2025-08-20: Purchase, 13,545 sh ($5.2M)2025-08-20: Purchase, 9,362 sh ($3.7M)2025-08-20: Purchase, 9,477 sh ($3.6M)2025-08-20: Purchase, 5,209 sh ($2.0M)2025-08-20: Purchase, 4,441 sh ($1.7M)2025-08-20: Purchase, 4,049 sh ($1.6M)2025-08-20: Purchase, 2,838 sh ($1.1M)2025-08-20: Purchase, 2,506 sh ($977K)2025-08-20: Purchase, 1,919 sh ($731K)2025-08-20: Purchase, 1,248 sh ($481K)2025-08-20: Purchase, 1,136 sh ($434K)2025-08-20: Purchase, 862 sh ($338K)2025-08-20: Purchase, 873 sh ($333K)2025-08-20: Purchase, 480 sh ($183K)2025-08-20: Purchase, 409 sh ($158K)2025-08-20: Purchase, 373 sh ($143K)2025-08-20: Purchase, 366 sh ($142K)2025-08-20: Purchase, 262 sh ($100K)2025-08-20: Purchase, 231 sh ($90K)2025-08-20: Purchase, 176 sh ($67K)2025-08-20: Purchase, 105 sh ($40K)2025-08-20: Purchase, 34 sh ($13K)2025-08-18: Purchase, 26,704 sh ($10.0M)2025-08-18: Purchase, 10,128 sh ($3.8M)2025-08-18: Purchase, 8,514 sh ($3.1M)2025-08-18: Purchase, 8,328 sh ($3.0M)2025-08-18: Purchase, 7,325 sh ($2.7M)2025-08-18: Purchase, 5,494 sh ($2.0M)2025-08-18: Purchase, 5,587 sh ($2.0M)2025-08-18: Purchase, 5,443 sh ($2.0M)2025-08-18: Purchase, 4,798 sh ($1.8M)2025-08-18: Purchase, 2,747 sh ($1.0M)2025-08-18: Purchase, 2,772 sh ($1.0M)2025-08-18: Purchase, 2,460 sh ($917K)2025-08-18: Purchase, 2,472 sh ($885K)2025-08-18: Purchase, 2,289 sh ($838K)2025-08-18: Purchase, 1,923 sh ($681K)2025-08-18: Purchase, 1,419 sh ($523K)2025-08-18: Purchase, 933 sh ($347K)2025-08-18: Purchase, 916 sh ($325K)2025-08-18: Purchase, 784 sh ($282K)2025-08-18: Purchase, 767 sh ($274K)2025-08-18: Purchase, 675 sh ($253K)2025-08-18: Purchase, 506 sh ($188K)2025-08-18: Purchase, 515 sh ($187K)2025-08-18: Purchase, 502 sh ($181K)2025-08-18: Purchase, 442 sh ($163K)2025-08-18: Purchase, 253 sh ($93K)2025-08-18: Purchase, 255 sh ($93K)2025-08-18: Purchase, 228 sh ($82K)2025-08-18: Purchase, 211 sh ($77K)2025-08-18: Purchase, 177 sh ($63K)2025-08-18: Purchase, 131 sh ($48K)2025-08-18: Purchase, 84 sh ($30K)2025-06-20: Award / grant, 1,430 sh ($0)2025-06-20: Award / grant, 2,580 sh ($0)2025-06-20: Award / grant, 1,430 sh ($0)
VTVT · 44 trades
2026-06-26: Award / grant, 6,000 sh ($0)2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 46,692 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 217,144 sh2025-09-03: Award / grant, 4,308 sh2025-09-03: Award / grant, 2,400,605 sh2025-09-03: Award / grant, 221,452 sh2025-09-03: Award / grant, 2,353,913 sh2025-09-03: Award / grant, 46,692 sh2025-06-10: Award / grant, 4,000 sh ($0)
DBVT · 32 trades
2026-01-12: Option exercise, 2,299,656 sh ($0)2026-01-12: Option exercise, 25,005,240 sh ($0)2026-01-12: Option exercise, 2,299,656 sh ($0)2026-01-12: Option exercise, 25,005,240 sh ($0)2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh2025-03-27: Award / grant, 2,299,656 sh2025-03-27: Award / grant, 25,005,240 sh
INCY · 23 trades
2026-06-30: Award / grant, 400 sh ($0)2026-06-30: Award / grant, 400 sh ($0)2026-06-08: Award / grant, 1,642 sh ($0)2026-06-08: Award / grant, 6,111 sh ($0)2026-06-08: Award / grant, 1,642 sh ($0)2026-05-08: Option exercise, 15,000 sh ($1.3M)2026-05-08: Option exercise, 15,000 sh ($1.3M)2026-05-08: Option exercise, 15,000 sh ($0)2026-03-31: Award / grant, 421 sh ($0)2026-03-31: Award / grant, 421 sh ($0)2025-12-31: Award / grant, 328 sh ($0)2025-12-31: Award / grant, 328 sh ($0)2025-09-30: Award / grant, 388 sh ($0)2025-09-30: Award / grant, 388 sh ($0)2025-06-30: Award / grant, 492 sh ($0)2025-06-30: Award / grant, 492 sh ($0)2025-06-10: Award / grant, 2,518 sh ($0)2025-06-10: Award / grant, 9,216 sh ($0)2025-06-10: Award / grant, 2,518 sh ($0)2025-03-31: Award / grant, 487 sh ($0)2025-03-31: Award / grant, 487 sh ($0)2024-12-31: Award / grant, 446 sh ($0)2024-12-31: Award / grant, 446 sh ($0)
IGMS · 22 trades
2025-08-14: Code U, 834,707 sh ($0)2025-08-14: Code U, 9,886,217 sh ($0)2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 3,763,362 sh2025-08-14: Code U, 357,048 sh2025-08-14: Code U, 357,048 sh2025-06-30: Award / grant, 953 sh ($0)2025-06-30: Award / grant, 953 sh ($0)2025-03-31: Award / grant, 953 sh ($0)2025-03-31: Award / grant, 953 sh ($0)2024-12-31: Award / grant, 1,994 sh ($0)2024-12-31: Award / grant, 1,994 sh ($0)
IMCR · 19 trades
2025-05-15: Award / grant, 26,198 sh ($0)2025-03-17: Purchase, 646,290 sh ($19.2M)2025-03-17: Purchase, 92,349 sh ($2.7M)2025-03-17: Purchase, 60,110 sh ($1.8M)2025-03-17: Purchase, 8,589 sh ($254K)2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale2025-03-17: Sale

Filing ledger

DateCompanyActionShares @ priceValueOwnership ΔOwned afterFiling
2026-08-11REPLPurchase2,609,946 @ $12.06$31.5Mownership Δ n/a2,609,946Form 4
2026-08-11REPLPurchase126,394 @ $12.06$1.5Mownership Δ n/a126,394Form 4
2026-07-14CELCSale2,838,632 @ $102.50$291.0M−39.4% of holding4,372,852Form 4
2026-07-14CELCSale261,368 @ $102.50$26.8M−37.1% of holding442,940Form 4
2026-05-22ONCSale2,756 @ $23.79$66K−1.9% of holding142,570Form 4
2026-05-22ONCSale2,756 @ $23.79$66K−1.9% of holding142,566Form 4
2026-05-22ONCSale2,743 @ $23.85$65K−1.9% of holding145,322Form 4
2026-05-22ONCSale2,743 @ $23.85$65K−1.9% of holding145,326Form 4
2026-04-21PRLDPurchase2,137,651 @ $4.44$9.5M+11.9% of holding20,105,994Form 4
2026-04-21PRLDPurchase114,601 @ $4.44$509K+7.3% of holding1,678,273Form 4
2025-12-18KODPurchase2,391,268 @ $23.00$55.0M+15.0% of holding18,358,772Form 4
2025-12-18KODPurchase217,428 @ $23.00$5.0M+16.2% of holding1,560,414Form 4
2025-12-11KYMRPurchase1,838,621 @ $86.00$158.1M+30.1% of holding7,955,916Form 4
2025-12-11DNLIPurchase2,095,191 @ $17.49$36.6M+8.8% of holding25,996,310Form 4
2025-12-11KYMRPurchase167,192 @ $86.00$14.4M+31.3% of holding701,326Form 4
2025-12-11DNLIPurchase190,523 @ $17.49$3.3M+8.9% of holding2,335,469Form 4
2025-11-20TRDAPurchase13,386 @ $9.07$121K+0.3% of holding4,678,310Form 4
2025-11-20TRDAPurchase13,082 @ $9.07$119K+0.3% of holding4,691,392Form 4
2025-11-20TRDAPurchase1,213 @ $9.07$11K+0.3% of holding380,152Form 4
2025-11-20TRDAPurchase1,186 @ $9.07$11K+0.3% of holding381,338Form 4
2025-11-12TRDAPurchase80,881 @ $7.73$625K+1.8% of holding4,653,430Form 4
2025-11-12TRDAPurchase11,494 @ $7.95$91K+0.2% of holding4,664,924Form 4
2025-11-12TRDAPurchase7,321 @ $7.73$57K+2.0% of holding377,899Form 4
2025-11-12TRDAPurchase1,040 @ $7.95$8K+0.3% of holding378,939Form 4
2025-11-11TRDAPurchase30,879 @ $7.54$233K+0.7% of holding4,572,549Form 4
2025-11-11TRDAPurchase11,701 @ $7.39$86K+0.3% of holding4,541,670Form 4
2025-11-11TRDAPurchase2,795 @ $7.54$21K+0.8% of holding370,578Form 4
2025-11-11TRDAPurchase1,059 @ $7.39$8K+0.3% of holding367,783Form 4
2025-11-10TRDAPurchase25,364 @ $7.21$183K+0.6% of holding4,527,022Form 4
2025-11-10TRDAPurchase2,947 @ $7.22$21K+0.1% of holding4,529,969Form 4
2025-11-10TRDAPurchase2,296 @ $7.21$17K+0.6% of holding366,457Form 4
2025-11-10TRDAPurchase267 @ $7.22$2K+0.1% of holding366,724Form 4
2025-10-01—Sale462,967 @ $1.38$641K−52.1% of holding425,006Form 4
2025-10-01—Sale50,640 @ $1.38$70K−52.1% of holding46,480Form 4
2025-09-30—Sale195,425 @ $1.60$312K−18.0% of holding887,973Form 4
2025-09-30—Sale21,376 @ $1.60$34K−18.0% of holding97,120Form 4
2025-09-08CELCPurchase151,524 @ $56.22$8.5M+2.1% of holding7,207,272Form 4
2025-09-08CELCPurchase13,976 @ $56.22$786K+2.0% of holding703,920Form 4
2025-09-08CELCPurchase4,212 @ $58.02$244K+0.1% of holding7,211,484Form 4
2025-09-08CELCPurchase388 @ $58.02$23K+0.1% of holding704,308Form 4
2025-08-20MDGLPurchase13,545 @ $385.06$5.2M+0.7% of holding1,931,293Form 4
2025-08-20MDGLPurchase9,362 @ $392.24$3.7M+0.5% of holding1,947,968Form 4
2025-08-20MDGLPurchase9,477 @ $381.12$3.6M+0.5% of holding1,909,725Form 4
2025-08-20MDGLPurchase5,209 @ $380.44$2.0M+0.3% of holding1,898,329Form 4
2025-08-20MDGLPurchase4,441 @ $387.07$1.7M+0.2% of holding1,935,734Form 4
2025-08-20MDGLPurchase4,049 @ $383.79$1.6M+0.2% of holding1,917,748Form 4
2025-08-20MDGLPurchase2,838 @ $382.82$1.1M+0.1% of holding1,913,699Form 4
2025-08-20MDGLPurchase2,506 @ $389.89$977K+0.1% of holding1,938,606Form 4
2025-08-20MDGLPurchase1,919 @ $380.78$731K+0.1% of holding1,900,248Form 4
2025-08-20MDGLPurchase1,248 @ $385.06$481K+0.6% of holding201,277Form 4
2025-08-20MDGLPurchase1,136 @ $382.29$434K+0.1% of holding1,910,861Form 4
2025-08-20MDGLPurchase862 @ $392.24$338K+0.4% of holding202,813Form 4
2025-08-20MDGLPurchase873 @ $381.12$333K+0.4% of holding199,289Form 4
2025-08-20MDGLPurchase480 @ $380.44$183K+0.2% of holding198,240Form 4
2025-08-20MDGLPurchase409 @ $387.07$158K+0.2% of holding201,686Form 4
2025-08-20MDGLPurchase373 @ $383.79$143K+0.2% of holding200,029Form 4
2025-08-20MDGLPurchase366 @ $389.00$142K+0.0% of holding1,936,100Form 4
2025-08-20MDGLPurchase262 @ $382.82$100K+0.1% of holding199,656Form 4
2025-08-20MDGLPurchase231 @ $389.89$90K+0.1% of holding201,951Form 4
2025-08-20MDGLPurchase176 @ $380.78$67K+0.1% of holding198,416Form 4
2025-08-20MDGLPurchase105 @ $382.29$40K+0.1% of holding199,394Form 4
2025-08-20MDGLPurchase34 @ $389.00$13K+0.0% of holding201,720Form 4
2025-08-18MDGLPurchase26,704 @ $372.87$10.0M+1.4% of holding1,885,795Form 4
2025-08-18MDGLPurchase10,128 @ $372.16$3.8M+0.5% of holding1,859,091Form 4
2025-08-18MDGLPurchase8,514 @ $359.39$3.1M+0.5% of holding1,818,414Form 4
2025-08-18MDGLPurchase8,328 @ $357.02$3.0M+0.5% of holding1,807,428Form 4
2025-08-18MDGLPurchase7,325 @ $374.43$2.7M+0.4% of holding1,893,120Form 4
2025-08-18MDGLPurchase5,494 @ $371.00$2.0M+0.3% of holding1,848,963Form 4
2025-08-18MDGLPurchase5,587 @ $362.39$2.0M+0.3% of holding1,829,444Form 4
2025-08-18MDGLPurchase5,443 @ $361.37$2.0M+0.3% of holding1,823,857Form 4
2025-08-18MDGLPurchase4,798 @ $367.77$1.8M+0.3% of holding1,839,303Form 4
2025-08-18MDGLPurchase2,747 @ $369.33$1.0M+0.1% of holding1,843,469Form 4
2025-08-18MDGLPurchase2,772 @ $363.75$1.0M+0.2% of holding1,832,216Form 4
2025-08-18MDGLPurchase2,460 @ $372.87$917K+1.3% of holding197,085Form 4
2025-08-18MDGLPurchase2,472 @ $358.21$885K+0.1% of holding1,809,900Form 4
2025-08-18MDGLPurchase2,289 @ $366.30$838K+0.1% of holding1,834,505Form 4
2025-08-18MDGLPurchase1,923 @ $353.88$681K+0.1% of holding1,798,184Form 4
2025-08-18MDGLPurchase1,419 @ $368.84$523K+0.1% of holding1,840,722Form 4
2025-08-18MDGLPurchase933 @ $372.16$347K+0.5% of holding194,625Form 4
2025-08-18MDGLPurchase916 @ $355.00$325K+0.1% of holding1,799,100Form 4
167 award / exercise / gift records — not counted as purchases
DateCompanyActionSharesOwned afterFiling
2026-06-30INCYAward / grant4002,835,081Form 4
2026-06-30KODAward / grant17,73117,731Form 4
2026-06-30INCYAward / grant40028,205,760Form 4
2026-06-26VTVTAward / grant6,0006,000Form 4
2026-06-24KYMRAward / grant6,0686,068Form 4
2026-06-17MDGLAward / grant9081,948,876Form 4
2026-06-17MDGLAward / grant1,5321,532Form 4
2026-06-17MDGLAward / grant908203,721Form 4
2026-06-11ONCAward / grant18,980161,546Form 4
2026-06-11ONCAward / grant18,980161,550Form 4
2026-06-09PRLDAward / grant38,00038,000Form 4
2026-06-08INCYAward / grant1,64228,205,360Form 4
2026-06-08INCYAward / grant6,1116,111Form 4
2026-06-08INCYAward / grant1,6422,834,681Form 4
2026-06-03DNLIAward / grant6,4083,422,366Form 4
2026-06-03DNLIAward / grant19,22619,226Form 4
2026-06-03DNLIAward / grant6,408343,275Form 4
2026-05-29KNSAAward / grant6,0782,744,894Form 4
2026-05-29ACADAward / grant32,00832,008Form 4
2026-05-29ACADAward / grant18,62239,384,587Form 4
2026-05-29ACADAward / grant18,6223,677,357Form 4
2026-05-29KNSAAward / grant36,47436,474Form 4
2026-05-29KNSAAward / grant6,078143,277Form 4
2026-05-20—Award / grant67,00067,000Form 4
2026-05-08INCYOption exercise15,00028,203,718Form 4
2026-05-08INCYOption exercise15,0002,833,039Form 4
2026-05-08INCYOption exercise15,0000Form 4
2026-04-01REPLAward / grant44,50044,500Form 4
2026-03-31INCYAward / grant42128,188,718Form 4
2026-03-31INCYAward / grant4212,818,039Form 4
2026-01-12DBVTOption exercise2,299,6560Form 4
2026-01-12DBVTOption exercise25,005,24025,005,240Form 4
2026-01-12DBVTOption exercise2,299,6562,299,656Form 4
2026-01-12DBVTOption exercise25,005,2400Form 4
2026-01-02BCYCAward / grant19,00010,018,674Form 4
2026-01-02BCYCAward / grant38,00038,000Form 4
2026-01-02BCYCAward / grant19,000937,483Form 4
2025-12-31INCYAward / grant32828,188,297Form 4
2025-12-31INCYAward / grant3282,817,618Form 4
2025-09-30INCYAward / grant38828,187,969Form 4

Source: SEC Form 4 filings. Each row links to its original filing.

Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.