ORBIMED ADVISORS LLC

Director · Ten-percent owner · SCTX, SION, ELVN, STTK, QTTB, PRLD …

As of 2026-09-16, ORBIMED ADVISORS LLC has 198 Form 4 transactions on record across 16 companies — 105 in the trailing 12 months.

Everything this person has disclosed to the SEC on Form 4 — across every company they file for — reconstructed from the public record. A filing history, not a tip sheet.

Pattern in the record: open-market purchases filed in August in multiple years since 2025 — a recurring calendar cadence, more consistent with scheduled activity than a one-off decision.

Reconstructed holdings

Direct: $0Indirect: $524.6M$524.6Mas of 2026-09-16
  • Direct $0
  • Indirect $524.6M
ELVNindirect6,555,102 sh$322.0M
MBXindirect747,887 sh$46.0M
NPCEindirect3,238,199 sh$45.7M
STTKindirect5,303,908 sh$31.2M
EWTXindirect443,792 sh$20.2M
SIONindirect2,469,959 sh$17.4M
IRONindirect186,541 sh$12.8M
SCTXindirect348,825 sh$10.2M
QTTBindirect625,000 sh$6.9M
PRLDindirect1,126,126 sh$5.0M

Reconstructed from this person's own Form 4 filings — the total each filing reported owning afterward, priced at the close on the as-of date shown. A filed position can lag the real one.

Direct and indirect holdings (e.g. through a trust or fund) are tagged separately, as filed.

Trades by company

STTK · 42 trades
2026-06-11: Purchase, 1,041,667 sh2026-06-11: Purchase, 208,333 sh2026-06-11: Purchase, 1,041,667 sh2026-06-11: Purchase, 208,333 sh2026-06-11: Purchase, 1,041,667 sh2026-06-11: Purchase, 208,333 sh2026-06-11: Purchase, 1,041,667 sh2026-06-11: Purchase, 208,333 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2026-06-08: Conversion, 3,073,298 sh2026-06-08: Conversion, 15,366,490 sh2025-08-25: Purchase, 5,255,106 sh ($4.6M)2025-08-25: Purchase, 1,051,021 sh ($912K)2025-08-25: Purchase, 3,073,298 sh2025-08-25: Purchase, 15,366,490 sh2025-08-25: Purchase, 2,022,277 sh2025-08-25: Purchase, 3,073,298 sh2025-08-25: Purchase, 2,022,277 sh2025-08-25: Purchase, 10,111,384 sh2025-08-25: Purchase, 10,111,384 sh2025-08-25: Purchase, 10,111,384 sh2025-08-25: Purchase, 3,073,298 sh2025-08-25: Purchase, 15,366,490 sh2025-08-25: Purchase, 2,022,277 sh2025-08-25: Purchase, 10,111,384 sh2025-08-25: Purchase, 15,366,490 sh2025-08-25: Purchase, 3,073,298 sh2025-08-25: Purchase, 15,366,490 sh2025-08-25: Purchase, 2,022,277 sh
IRON · 27 trades
2025-03-24: Sale, 3,026 sh ($164K)2025-03-24: Sale, 1,956 sh ($106K)2025-03-24: Sale, 756 sh ($41K)2025-03-21: Sale, 5,279 sh ($285K)2025-03-21: Sale, 3,412 sh ($184K)2025-03-21: Sale, 1,320 sh ($71K)2025-03-20: Sale, 1,457 sh ($79K)2025-03-20: Sale, 941 sh ($51K)2025-03-20: Sale, 364 sh ($20K)2025-03-19: Sale, 20,911 sh ($1.1M)2025-03-19: Sale, 13,517 sh ($730K)2025-03-19: Sale, 5,228 sh ($282K)2025-03-12: Sale, 42,930 sh ($2.3M)2025-03-12: Sale, 27,750 sh ($1.5M)2025-03-12: Sale, 10,733 sh ($584K)2025-03-12: Sale, 933 sh ($51K)2025-03-12: Sale, 603 sh ($33K)2025-03-12: Sale, 233 sh ($13K)2025-03-11: Sale, 14,267 sh ($771K)2025-03-11: Sale, 9,222 sh ($498K)2025-03-11: Sale, 3,567 sh ($193K)2025-03-10: Sale, 106,384 sh ($5.8M)2025-03-10: Sale, 68,766 sh ($3.7M)2025-03-10: Sale, 26,596 sh ($1.4M)2025-03-10: Sale, 211 sh ($12K)2025-03-10: Sale, 136 sh ($7K)2025-03-10: Sale, 53 sh ($3K)
SION · 26 trades
2026-07-07: Sale, 85,918 sh ($3.9M)2026-06-30: Sale, 115,844 sh ($5.3M)2026-05-27: Sale, 101 sh ($4K)2026-05-11: Sale, 184,639 sh ($8.5M)2026-05-08: Sale, 59,767 sh ($2.7M)2026-05-07: Sale, 48,546 sh ($2.2M)2026-04-18: Sale, 2,948 sh ($131K)2026-04-17: Sale, 52,397 sh ($2.3M)2026-04-16: Sale, 226,906 sh ($10.3M)2026-04-15: Sale, 235,863 sh ($10.5M)2026-04-14: Sale, 47,814 sh ($2.1M)2026-02-03: Sale, 29,063 sh ($1.3M)2026-02-02: Sale, 1,890 sh ($84K)2025-12-24: Sale, 33,356 sh ($1.5M)2025-12-19: Sale, 875 sh ($39K)2025-12-18: Sale, 100 sh ($4K)2025-12-17: Sale, 900 sh ($40K)2025-11-26: Sale, 1,600 sh ($71K)2025-11-25: Sale, 11,890 sh ($530K)2025-11-24: Sale, 94,583 sh ($4.2M)2025-02-10: Purchase, 550,000 sh ($9.9M)2025-02-10: Conversion, 2,048,760 sh ($0)2025-02-10: Conversion, 2,560,951 sh ($0)2025-02-10: Conversion, 3,154,959 sh2025-02-10: Conversion, 3,154,959 sh2025-02-10: Conversion, 3,154,959 sh
IMA · 8 trades
2026-04-14: Purchase, 336,603 sh2026-04-14: Purchase, 384,689 sh2026-04-14: Purchase, 336,603 sh2026-04-14: Purchase, 384,689 sh2026-04-14: Purchase, 336,603 sh2026-04-14: Purchase, 384,689 sh2026-04-14: Purchase, 336,603 sh2026-04-14: Purchase, 384,689 sh
ELVN · 6 trades
2026-06-22: Sale, 787,024 sh ($35.7M)2026-06-22: Sale, 46,776 sh ($2.1M)2026-06-22: Sale, 24,846 sh ($1.1M)2026-06-22: Sale, 1,477 sh ($66K)2026-06-15: Sale, 272,322 sh ($12.3M)2026-06-15: Sale, 9,086 sh ($409K)
ACET · 6 trades
2026-04-08: Sale, 40,416 sh ($264K)2026-04-08: Sale, 32,523 sh ($205K)2026-04-07: Sale, 29,319 sh ($191K)2026-04-07: Sale, 2,400 sh ($15K)2025-10-08: Purchase, 3,500,000 sh ($3.5M)2025-10-08: Purchase, 1,500,000 sh ($1.5M)

Filing ledger

DateCompanyActionShares @ priceValueOwnership ΔOwned afterFiling
2026-08-10—Purchase625,000 @ $16.00$10.0M+29.9% of holding2,714,279Form 4
2026-08-07—Purchase1,666,667 @ $18.00$30.0M+16.3% of holding11,901,826Form 4
2026-08-07—Purchase273,333 @ $18.00$4.9Mownership Δ n/a273,333Form 4
2026-07-27SCTXPurchase1,000,000 @ $15.00$15.0M+286.7% of holding1,348,825Form 4
2026-07-07SIONSale85,918 @ $44.86$3.9M−3.4% of holding2,469,959Form 4
2026-06-30SIONSale115,844 @ $45.50$5.3M−4.3% of holding2,555,877Form 4
2026-06-22ELVNSale787,024 @ $45.38$35.7M−10.7% of holding6,601,878Form 4
2026-06-22ELVNSale46,776 @ $45.00$2.1M−0.7% of holding6,555,102Form 4
2026-06-22ELVNSale24,846 @ $45.38$1.1M−10.1% of holding220,882Form 4
2026-06-22ELVNSale1,477 @ $45.00$66K−0.7% of holding219,405Form 4
2026-06-15ELVNSale272,322 @ $45.02$12.3M−3.6% of holding7,388,902Form 4
2026-06-15ELVNSale9,086 @ $45.02$409K−3.6% of holding245,728Form 4
2026-06-11STTKPurchase1,041,667—+4.1% of holding26,519,541Form 4
2026-06-11STTKPurchase208,333—+4.1% of holding5,303,908Form 4
2026-06-11STTKPurchase1,041,667—+4.1% of holding26,519,541Form 4
2026-06-11STTKPurchase208,333—+4.1% of holding5,303,908Form 4
2026-06-11STTKPurchase1,041,667—+4.1% of holding26,519,541Form 4
2026-06-11STTKPurchase208,333—+4.1% of holding5,303,908Form 4
2026-06-11STTKPurchase1,041,667—+4.1% of holding26,519,541Form 4
2026-06-11STTKPurchase208,333—+4.1% of holding5,303,908Form 4
2026-05-28QTTBPurchase1,250,000 @ $8.00$10.0M+55.5% of holding3,502,987Form 4
2026-05-28QTTBPurchase625,000 @ $8.00$5.0Mownership Δ n/a625,000Form 4
2026-05-27SIONSale101 @ $44.49$4K−0.0% of holding2,671,721Form 4
2026-05-11SIONSale184,639 @ $46.22$8.5M−6.5% of holding2,671,822Form 4
2026-05-08SIONSale59,767 @ $44.58$2.7M−2.0% of holding2,856,461Form 4
2026-05-07SIONSale48,546 @ $44.61$2.2M−1.6% of holding2,916,228Form 4
2026-04-21PRLDPurchase1,689,189 @ $4.44$7.5M+16.7% of holding11,808,945Form 4
2026-04-21PRLDPurchase1,126,126 @ $4.44$5.0Mownership Δ n/a1,126,126Form 4
2026-04-18SIONSale2,948 @ $44.52$131K−0.1% of holding2,964,774Form 4
2026-04-17SIONSale52,397 @ $44.68$2.3M−1.7% of holding2,967,722Form 4
2026-04-16SIONSale226,906 @ $45.34$10.3M−7.0% of holding3,020,119Form 4
2026-04-16—Purchase597,729 @ $1.67$998K+98.7% of holding1,203,250Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-16—Purchase1,793,187—ownership Δ n/a1,793,187Form 4
2026-04-16—Purchase1,793,187—ownership Δ n/a1,793,187Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-16—Purchase1,793,187—ownership Δ n/a1,793,187Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-16—Purchase597,729—ownership Δ n/a597,729Form 4
2026-04-15SIONSale235,863 @ $44.64$10.5M−6.8% of holding3,247,025Form 4
2026-04-14SIONSale47,814 @ $44.51$2.1M−1.4% of holding3,482,888Form 4
2026-04-14IMAPurchase336,603—ownership Δ n/a336,603Form 4
2026-04-14IMAPurchase384,689—ownership Δ n/a384,689Form 4
2026-04-14IMAPurchase336,603—ownership Δ n/a336,603Form 4
2026-04-14IMAPurchase384,689—ownership Δ n/a384,689Form 4
2026-04-14IMAPurchase336,603—ownership Δ n/a336,603Form 4
2026-04-14IMAPurchase384,689—ownership Δ n/a384,689Form 4
2026-04-14IMAPurchase336,603—ownership Δ n/a336,603Form 4
2026-04-14IMAPurchase384,689—ownership Δ n/a384,689Form 4
2026-04-08ACETSale40,416 @ $6.52$264K−100.0% of holding0Form 4
2026-04-08ACETSale32,523 @ $6.29$205K−100.0% of holding0Form 4
2026-04-07ACETSale29,319 @ $6.53$191K−45.6% of holding34,923Form 4
2026-04-07ACETSale2,400 @ $6.38$15K−6.9% of holding32,523Form 4
2026-02-03SIONSale29,063 @ $44.58$1.3M−0.8% of holding3,530,702Form 4
2026-02-02SIONSale1,890 @ $44.57$84K−0.1% of holding3,559,765Form 4
2025-12-24SIONSale33,356 @ $44.55$1.5M−0.9% of holding3,561,655Form 4
2025-12-19SIONSale875 @ $44.49$39K−0.0% of holding3,595,011Form 4
2025-12-18SIONSale100 @ $44.49$4K−0.0% of holding3,595,886Form 4
2025-12-17SIONSale900 @ $44.50$40K−0.0% of holding3,595,986Form 4
2025-11-26SIONSale1,600 @ $44.49$71K−0.0% of holding3,596,886Form 4
2025-11-25SIONSale11,890 @ $44.60$530K−0.3% of holding3,598,486Form 4
2025-11-24SIONSale94,583 @ $44.54$4.2M−2.6% of holding3,610,376Form 4
2025-10-08ACETPurchase3,500,000 @ $1.00$3.5M+353.4% of holding4,490,254Form 4
2025-10-08ACETPurchase1,500,000 @ $1.00$1.5M+19.9% of holding9,026,359Form 4
2025-08-25STTKPurchase5,255,106 @ $0.87$4.6Mownership Δ n/a5,255,106Form 4
2025-08-25STTKPurchase1,051,021 @ $0.87$912Kownership Δ n/a1,051,021Form 4
2025-08-25STTKPurchase3,073,298—ownership Δ n/a3,073,298Form 4
2025-08-25STTKPurchase15,366,490—ownership Δ n/a15,366,490Form 4
2025-08-25STTKPurchase2,022,277—ownership Δ n/a2,022,277Form 4
2025-08-25STTKPurchase3,073,298—ownership Δ n/a3,073,298Form 4
2025-08-25STTKPurchase2,022,277—ownership Δ n/a2,022,277Form 4
2025-08-25STTKPurchase10,111,384—ownership Δ n/a10,111,384Form 4
2025-08-25STTKPurchase10,111,384—ownership Δ n/a10,111,384Form 4
2025-08-25STTKPurchase10,111,384—ownership Δ n/a10,111,384Form 4
2025-08-25STTKPurchase3,073,298—ownership Δ n/a3,073,298Form 4
2025-08-25STTKPurchase15,366,490—ownership Δ n/a15,366,490Form 4
2025-08-25STTKPurchase2,022,277—ownership Δ n/a2,022,277Form 4
2025-08-25STTKPurchase10,111,384—ownership Δ n/a10,111,384Form 4
50 award / exercise / gift records — not counted as purchases
DateCompanyActionSharesOwned afterFiling
2026-08-10—Conversion1,049,2830Form 4
2026-08-10—Conversion1,039,9960Form 4
2026-08-10—Conversion1,039,9961,039,996Form 4
2026-08-10—Conversion1,049,2832,089,279Form 4
2026-08-10—Conversion1,039,9961,039,996Form 4
2026-08-10—Conversion1,049,2832,089,279Form 4
2026-08-10—Conversion1,039,9961,039,996Form 4
2026-08-10—Conversion1,049,2832,089,279Form 4
2026-08-07—Conversion40,000,0000Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-08-07—Conversion9,132,42010,235,159Form 4
2026-07-27SCTXConversion2,065,6720Form 4
2026-07-27SCTXConversion348,825348,825Form 4
2026-07-27SCTXConversion348,825348,825Form 4
2026-07-27SCTXConversion348,825348,825Form 4
2026-06-08STTKConversion15,366,49025,477,874Form 4
2026-06-08STTKConversion3,073,2980Form 4
2026-06-08STTKConversion15,366,4900Form 4
2026-06-08STTKConversion3,073,2985,095,575Form 4
2026-06-08STTKConversion15,366,49025,477,874Form 4
2026-06-08STTKConversion3,073,2980Form 4
2026-06-08STTKConversion15,366,4900Form 4
2026-06-08STTKConversion3,073,2985,095,575Form 4
2026-06-08STTKConversion3,073,2980Form 4
2026-06-08STTKConversion15,366,4900Form 4
2026-06-08STTKConversion3,073,2985,095,575Form 4
2026-06-08STTKConversion15,366,49025,477,874Form 4
2026-06-08STTKConversion3,073,2980Form 4
2026-06-08STTKConversion15,366,4900Form 4
2026-06-08STTKConversion3,073,2985,095,575Form 4
2026-06-08STTKConversion15,366,49025,477,874Form 4
2025-11-21KROSDisposition140,057759,155Form 4
2025-11-21KROSDisposition74,46545,057Form 4
2025-08-08—Code U3,099,2650Form 4

Source: SEC Form 4 filings. Each row links to its original filing.

Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.