SIONSionna Therapeutics, Inc.Healthcare · Biotechnologyas of 2026-09-16
Horizon

Issued 2026-09-16 at $7.04 · now $7.04 (2026-09-16, +0.0% since)

Based on its own history, a month from the 2026-09-16 close, SION has typically landed between $4.46 and $10.17 — a range of −36.7% to +44.5% from the issuance price $7.04.

Range of outcomes in historically similar periods — not a price prediction. Ranges are scored publicly on /methodology.
  • Actual close
  • Typical path (median)
  • Middle 50% of outcomes
  • 90% range

382 overlapping 1 month windows · 2025-02-072026-08-17 · basis climatology · forecast (batch). Probability up 53.9% (90% CI 51.756.1%, ≈1,408 obs).

The cone is anchored at the 2026-09-16 issuance close ($7.04) — the price the forecast resolves against on 2026-10-15, not the latest close. The drawn path shape is illustrative (bands widen with √t); every labeled number is real — the anchor, the scored batch p90/IQR endpoints, and the typical move.

Where SION has typically landed a month from the 2026-09-16 close of $7.04 — the range is history, not a prediction.

$4.46worst · -36.7%$10.17best · +44.5%
  • now $7.04 (+0.0%)
  • typicalThe typical outcome — half of similar past periods did better and half did worse (not an average, so a few wild periods don't skew it). $7.55 (+7.2%)
  • middle 50%The central range of outcomes — half of similar past periods landed inside it, a quarter finished above, a quarter below. $6.59$8.51
  • 90% rangeA nine-in-ten range — in about nine of every ten similar past periods the outcome stayed within these bounds. $4.46$10.17
Actual 1-month windows behind the coneiEvery overlapping 1-month window in this security's own price history was ranked by realized return; shown are the 3 worst and 3 best of 382 windows spanning 2025-02-07 to 2026-09-16. Not cherry-picked — these are the extremes of the full sample. Max drop / max rise are the deepest and highest points reached within each window. See /methodology.
StartReturnMax dropMax rise
3 worst
2026-07-10−90.1%−90.1%+12.7%
2026-07-13−88.4%−89.8%+16.1%
2026-07-17−88.0%−90.9%+3.3%
3 best
2025-04-10+68.4%+0.0%+77.3%
2026-08-10+66.2%+0.0%+66.2%
2025-09-22+64.2%+0.0%+64.2%

382 overlapping windows · 2025-02-072026-09-16 · not cherry-picked

Seasonality · by month iHow this security has tended to do in each calendar month historically — a frequency, never a prediction.

iFor each calendar month, the share of years this security closed higher than the month before, and the average month-over-month return, over ~2 years of its own price history. Cells are shaded by average return. This is historical frequency, not a prediction — no month is a signal.
Jan
100%
+2.7%
n=1
Feb
0%
−13.5%
n=1
Mar
50%
−7.2%
n=2
Apr
50%
+5.8%
n=2
May
100%
+12.2%
n=2
Jun
100%
+14.7%
n=2
Jul
50%
+1.9%
n=2
Aug
50%
−20.2%
n=2
Sep
100%
+18.1%
n=2
Oct
100%
+29.9%
n=1
Nov
100%
+14.0%
n=1
Dec
0%
−5.6%
n=1

Up-frequency and average month-over-month return · historical frequency, not a prediction

Reported insider & political trades

Every Form 4 the people closest to this company have filed with the SEC — plotted against the share price, aggregated by month, and shown with the gap between when each trade happened and when it was disclosed. A public record, not advice.

Share price & reported tradesMonthly open-market valueReporting lag — trade date to filing date2026-092026-082026-072026-062026-052026-042026-032026-022026-012025-122025-112025-102025-092025-08$51$52026-07-07: 2 insider sales, $7.7M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-07-06: 1 insider sale, $447K — Fitzpatrick Jennifer2026-06-30: 2 insider sales, $10.5M — Thompson Peter A., ORBIMED ADVISORS LLC2026-05-27: 2 insider sales, $9K — ORBIMED ADVISORS LLC, Thompson Peter A.2026-05-11: 2 insider sales, $17.1M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-05-08: 2 insider sales, $5.3M — Thompson Peter A., ORBIMED ADVISORS LLC2026-05-07: 2 insider sales, $4.3M — Thompson Peter A., ORBIMED ADVISORS LLC2026-04-18: 2 insider sales, $262K — ORBIMED ADVISORS LLC, Thompson Peter A.2026-04-17: 2 insider sales, $4.7M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-04-16: 2 insider sales, $20.6M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-04-15: 2 insider sales, $21.1M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-04-14: 2 insider sales, $4.3M — Thompson Peter A., ORBIMED ADVISORS LLC2026-03-05: 1 insider sale, $347K — Fitzpatrick Jennifer2026-02-03: 2 insider sales, $2.6M — ORBIMED ADVISORS LLC, Thompson Peter A.2026-02-02: 2 insider sales, $168K — Thompson Peter A., ORBIMED ADVISORS LLC2026-01-22: 1 insider sale, $10.0M — TPG GP A, LLC2025-12-24: 2 insider sales, $3.0M — Thompson Peter A., ORBIMED ADVISORS LLC2025-12-19: 2 insider sales, $78K — ORBIMED ADVISORS LLC, Thompson Peter A.2025-12-18: 2 insider sales, $9K — Thompson Peter A., ORBIMED ADVISORS LLC2025-12-17: 2 insider sales, $80K — Thompson Peter A., ORBIMED ADVISORS LLC2025-12-05: 1 insider sale, $415K — Fitzpatrick Jennifer2025-11-26: 2 insider sales, $142K — Thompson Peter A., ORBIMED ADVISORS LLC2025-11-25: 2 insider sales, $1.1M — ORBIMED ADVISORS LLC, Thompson Peter A.2025-11-24: 2 insider sales, $8.4M — Thompson Peter A., ORBIMED ADVISORS LLC2025-11-21: 4 insider sales, $995K — RA CAPITAL MANAGEMENT, L.P. …2025-11-20: 8 insider sales, $206K — RA CAPITAL MANAGEMENT, L.P. …2025-11-19: 8 insider sales, $1.9M — RA CAPITAL MANAGEMENT, L.P. …2025-11-18: 4 insider sales, $274K — RA CAPITAL MANAGEMENT, L.P. …2025-11-17: 12 insider sales, $3.3M — RA CAPITAL MANAGEMENT, L.P. …2025-10-28: 4 insider sales, $2.5M — RA CAPITAL MANAGEMENT, L.P. …2025-10-24: 4 insider sales, $12.3M — RA CAPITAL MANAGEMENT, L.P. …2025-10-21: 14 insider sales, $6.7M — Cloonan Michael, Booth Bruce …2025-10-20: 4 insider sales, $1.8M — Booth Bruce …2025-10-17: 6 insider sales, $2.0M — Booth Bruce …2025-10-16: 10 insider sales, $5.8M — Booth Bruce, Cloonan Michael …2025-10-15: 5 insider sales, $4.0M — Booth Bruce, Cloonan Michael …2025-10-14: 2 insider sales, $18K — Booth Bruce …2025-10-13: 4 insider sales, $1.8M — Booth Bruce …2025-10-10: 2 insider sales, $607K — Booth Bruce …2025-10-06: 2 insider sales, $353K — Booth Bruce …2025-10-03: 2 insider sales, $1.1M — Booth Bruce …2025-10-01: 2 insider sales, $6K — Booth Bruce …2025-09-30: 2 insider sales, $372K — Booth Bruce …2025-09-29: 3 insider sales, $2.2M — Booth Bruce, Cloonan Michael …2025-09-26: 1 insider sale, $496K — Cloonan Michael2025-09-04: 1 insider sale, $237K — Fitzpatrick Jennifer2025-09-02: 1 insider sale, $222K — Ridloff Elena2025-08-29: 1 insider sale, $19K — Ridloff Elena2025-08-28: 1 insider sale, $418K — Ridloff Elena2025-08-27: 2 insider sales, $277K — Cloonan Michael, Ridloff Elena2025-08-26: 2 insider sales, $532K — Cloonan Michael, Ridloff Elena2025-08-20: 2 insider sales, $966K — Cloonan Michael, Ridloff Elena2025-08-19: 1 insider sale, $727K — Ridloff Elena2025-08: 9 open-market sales, $2.9M2025-09: 8 open-market sales, $3.5M2025-10: 61 open-market sales, $38.9M2025-11: 42 open-market sales, $16.3M2025-12: 9 open-market sales, $3.6M2026-01: 1 open-market sale, $10.0M2026-02: 4 open-market sales, $2.8M2026-03: 1 open-market sale, $347K2026-04: 10 open-market sales, $50.8M2026-05: 8 open-market sales, $26.7M2026-06: 2 open-market sales, $10.5M2026-07: 3 open-market sales, $8.2M↑ buys↓ salesdirector ORBIMED ADVISORS LLC — Sale on 2026-07-07, filed 2 days after the tradedirector Thompson Peter A. — Sale on 2026-07-07, filed 2 days after the tradeofficer Fitzpatrick Jennifer — Sale on 2026-07-06, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2026-06-30, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-06-30, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-05-27, filed 2 days after the tradedirector Thompson Peter A. — Sale on 2026-05-27, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-05-11, filed same daydirector Thompson Peter A. — Sale on 2026-05-11, filed same daydirector Thompson Peter A. — Sale on 2026-05-08, filed 3 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-05-08, filed 3 days after the tradedirector Thompson Peter A. — Sale on 2026-05-07, filed 4 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-05-07, filed 4 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-04-18, filed 3 days after the tradedirector Thompson Peter A. — Sale on 2026-04-18, filed 3 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-04-17, filed 4 days after the tradedirector Thompson Peter A. — Sale on 2026-04-17, filed 4 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-04-16, filed same daydirector Thompson Peter A. — Sale on 2026-04-16, filed same daydirector ORBIMED ADVISORS LLC — Sale on 2026-04-15, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2026-04-15, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2026-04-14, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-04-14, filed 2 days after the tradeofficer Fitzpatrick Jennifer — Sale on 2026-03-05, filed 1 day after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-02-03, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2026-02-03, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2026-02-02, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2026-02-02, filed 2 days after the tradeother TPG GP A, LLC — Sale on 2026-01-22, filed 4 days after the tradedirector Thompson Peter A. — Sale on 2025-12-24, filed 5 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2025-12-24, filed 5 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2025-12-19, filed same daydirector Thompson Peter A. — Sale on 2025-12-19, filed same daydirector Thompson Peter A. — Sale on 2025-12-18, filed 1 day after the tradedirector ORBIMED ADVISORS LLC — Sale on 2025-12-18, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2025-12-17, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2025-12-17, filed 2 days after the tradeofficer Fitzpatrick Jennifer — Sale on 2025-12-05, filed 4 days after the tradedirector Thompson Peter A. — Sale on 2025-11-26, filed same daydirector ORBIMED ADVISORS LLC — Sale on 2025-11-26, filed same daydirector ORBIMED ADVISORS LLC — Sale on 2025-11-25, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2025-11-25, filed 1 day after the tradedirector Thompson Peter A. — Sale on 2025-11-24, filed 2 days after the tradedirector ORBIMED ADVISORS LLC — Sale on 2025-11-24, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-21, filed 3 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-21, filed 3 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-21, filed 3 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-21, filed 3 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-20, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-19, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-18, filed 1 day after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-18, filed 1 day after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-18, filed 1 day after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-18, filed 1 day after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-11-17, filed 2 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-28, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-28, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-28, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-28, filed same daydirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-24, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-24, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-24, filed 4 days after the tradedirector RA CAPITAL MANAGEMENT, L.P. — Sale on 2025-10-24, filed 4 days after the tradedirector Cloonan Michael — Sale on 2025-10-21, filed 1 day after the tradedirector Cloonan Michael — Sale on 2025-10-21, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Cloonan Michael — Sale on 2025-10-21, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Cloonan Michael — Sale on 2025-10-21, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-21, filed same daydirector Booth Bruce — Sale on 2025-10-20, filed same daydirector Booth Bruce — Sale on 2025-10-20, filed same daydirector Booth Bruce — Sale on 2025-10-20, filed same daydirector Booth Bruce — Sale on 2025-10-20, filed same daydirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-17, filed 3 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Cloonan Michael — Sale on 2025-10-16, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-16, filed 4 days after the tradedirector Cloonan Michael — Sale on 2025-10-16, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-15, filed same daydirector Booth Bruce — Sale on 2025-10-15, filed same daydirector Cloonan Michael — Sale on 2025-10-15, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-10-15, filed same daydirector Booth Bruce — Sale on 2025-10-15, filed same daydirector Booth Bruce — Sale on 2025-10-14, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-14, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-13, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-10-13, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-10-13, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-10-13, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-10-10, filed 5 days after the tradedirector Booth Bruce — Sale on 2025-10-10, filed 5 days after the tradedirector Booth Bruce — Sale on 2025-10-06, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-06, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-10-03, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-03, filed 4 days after the tradedirector Booth Bruce — Sale on 2025-10-01, filed same daydirector Booth Bruce — Sale on 2025-10-01, filed same daydirector Booth Bruce — Sale on 2025-09-30, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-09-30, filed 1 day after the tradedirector Booth Bruce — Sale on 2025-09-29, filed 2 days after the tradedirector Booth Bruce — Sale on 2025-09-29, filed 2 days after the tradedirector Cloonan Michael — Sale on 2025-09-29, filed 1 day after the tradedirector Cloonan Michael — Sale on 2025-09-26, filed 4 days after the tradeofficer Fitzpatrick Jennifer — Sale on 2025-09-04, filed 1 day after the tradedirector Ridloff Elena — Sale on 2025-09-02, filed 1 day after the tradedirector Ridloff Elena — Sale on 2025-08-29, filed 5 days after the tradedirector Ridloff Elena — Sale on 2025-08-28, filed same daydirector Cloonan Michael — Sale on 2025-08-27, filed 1 day after the tradedirector Ridloff Elena — Sale on 2025-08-27, filed 1 day after the tradedirector Cloonan Michael — Sale on 2025-08-26, filed 2 days after the tradedirector Ridloff Elena — Sale on 2025-08-26, filed 2 days after the tradedirector Cloonan Michael — Sale on 2025-08-20, filed 1 day after the tradedirector Ridloff Elena — Sale on 2025-08-20, filed 1 day after the tradedirector Ridloff Elena — Sale on 2025-08-19, filed 2 days after the trade
DatePersonRoleActionShares @ priceValueOwnership Δvs S&P 1mvs S&P 6mOwned afterFiling
2026-07-07ORBIMED ADVISORS LLCdirectorSale85,918 @ $44.86$3.9M−3.4% of holding+2.4%not yet — horizon still open2,469,959Form 4 · filed 2 days after the trade
2026-07-07Thompson Peter A.directorSale85,918 @ $44.86$3.9M−3.4% of holding+2.4%not yet — horizon still open2,469,959Form 4 · filed 2 days after the trade
2026-07-06Fitzpatrick JenniferofficerSale10,250 @ $43.60$447K−100.0% of holding+13.1%not yet — horizon still open0Form 4 · filed 1 day after the trade
2026-06-30Thompson Peter A.directorSale115,844 @ $45.50$5.3M−4.3% of holding+7.0%not yet — horizon still open2,555,877Form 4 · filed 2 days after the trade
2026-06-30ORBIMED ADVISORS LLCdirectorSale115,844 @ $45.50$5.3M−4.3% of holding+7.0%not yet — horizon still open2,555,877Form 4 · filed 2 days after the trade
2026-05-27ORBIMED ADVISORS LLCdirectorSale101 @ $44.49$4K−0.0% of holding−0.3%not yet — horizon still open2,671,721Form 4 · filed 2 days after the trade
2026-05-27Thompson Peter A.directorSale101 @ $44.49$4K−0.0% of holding−0.3%not yet — horizon still open2,671,721Form 4 · filed 2 days after the trade
2026-05-11ORBIMED ADVISORS LLCdirectorSale184,639 @ $46.22$8.5M−6.5% of holding−24.1%not yet — horizon still open2,671,822Form 4 · filed same day
2026-05-11Thompson Peter A.directorSale184,639 @ $46.22$8.5M−6.5% of holding−24.1%not yet — horizon still open2,671,822Form 4 · filed same day
2026-05-08Thompson Peter A.directorSale59,767 @ $44.58$2.7M−2.0% of holding−23.8%not yet — horizon still open2,856,461Form 4 · filed 3 days after the trade
2026-05-08ORBIMED ADVISORS LLCdirectorSale59,767 @ $44.58$2.7M−2.0% of holding−23.8%not yet — horizon still open2,856,461Form 4 · filed 3 days after the trade
2026-05-07Thompson Peter A.directorSale48,546 @ $44.61$2.2M−1.6% of holding−23.7%not yet — horizon still open2,916,228Form 4 · filed 4 days after the trade
2026-05-07ORBIMED ADVISORS LLCdirectorSale48,546 @ $44.61$2.2M−1.6% of holding−23.7%not yet — horizon still open2,916,228Form 4 · filed 4 days after the trade
2026-04-18ORBIMED ADVISORS LLCdirectorSale2,948 @ $44.52$131K−0.1% of holding−13.9%not yet — horizon still open2,964,774Form 4 · filed 3 days after the trade
2026-04-18Thompson Peter A.directorSale2,948 @ $44.52$131K−0.1% of holding−13.9%not yet — horizon still open2,964,774Form 4 · filed 3 days after the trade
2026-04-17ORBIMED ADVISORS LLCdirectorSale52,397 @ $44.68$2.3M−1.7% of holding−13.9%not yet — horizon still open2,967,722Form 4 · filed 4 days after the trade
2026-04-17Thompson Peter A.directorSale52,397 @ $44.68$2.3M−1.7% of holding−13.9%not yet — horizon still open2,967,722Form 4 · filed 4 days after the trade
2026-04-16ORBIMED ADVISORS LLCdirectorSale226,906 @ $45.34$10.3M−7.0% of holding−16.4%not yet — horizon still open3,020,119Form 4 · filed same day
2026-04-16Thompson Peter A.directorSale226,906 @ $45.34$10.3M−7.0% of holding−16.4%not yet — horizon still open3,020,119Form 4 · filed same day
2026-04-15ORBIMED ADVISORS LLCdirectorSale235,863 @ $44.64$10.5M−6.8% of holding−12.0%not yet — horizon still open3,247,025Form 4 · filed 1 day after the trade
2026-04-15Thompson Peter A.directorSale235,863 @ $44.64$10.5M−6.8% of holding−12.0%not yet — horizon still open3,247,025Form 4 · filed 1 day after the trade
2026-04-14Thompson Peter A.directorSale47,814 @ $44.51$2.1M−1.4% of holding−7.3%not yet — horizon still open3,482,888Form 4 · filed 2 days after the trade
2026-04-14ORBIMED ADVISORS LLCdirectorSale47,814 @ $44.51$2.1M−1.4% of holding−7.3%not yet — horizon still open3,482,888Form 4 · filed 2 days after the trade
2026-03-05Fitzpatrick JenniferofficerSale10,250 @ $33.86$347K−100.0% of holding+11.2%−94.6%0Form 4 · filed 1 day after the trade
2026-02-03ORBIMED ADVISORS LLCdirectorSale29,063 @ $44.58$1.3M−0.8% of holding−21.1%−5.8%3,530,702Form 4 · filed 1 day after the trade
2026-02-03Thompson Peter A.directorSale29,063 @ $44.58$1.3M−0.8% of holding−21.1%−5.8%3,530,702Form 4 · filed 1 day after the trade
2026-02-02Thompson Peter A.directorSale1,890 @ $44.57$84K−0.1% of holding−19.3%+2.9%3,559,765Form 4 · filed 2 days after the trade
2026-02-02ORBIMED ADVISORS LLCdirectorSale1,890 @ $44.57$84K−0.1% of holding−19.3%+2.9%3,559,765Form 4 · filed 2 days after the trade
2026-01-22TPG GP A, LLCotherSale250,000 @ $40.00$10.0M−3.7% of holding−12.6%+1.6%6,494,962Form 4 · filed 4 days after the trade
2025-12-24Thompson Peter A.directorSale33,356 @ $44.55$1.5M−0.9% of holding−2.2%−10.3%3,561,655Form 4 · filed 5 days after the trade
2025-12-24ORBIMED ADVISORS LLCdirectorSale33,356 @ $44.55$1.5M−0.9% of holding−2.2%−10.3%3,561,655Form 4 · filed 5 days after the trade
2025-12-19ORBIMED ADVISORS LLCdirectorSale875 @ $44.49$39K−0.0% of holding−2.6%−11.3%3,595,011Form 4 · filed same day
2025-12-19Thompson Peter A.directorSale875 @ $44.49$39K−0.0% of holding−2.6%−11.3%3,595,011Form 4 · filed same day
2025-12-18Thompson Peter A.directorSale100 @ $44.49$4K−0.0% of holding−9.4%−19.2%3,595,886Form 4 · filed 1 day after the trade
2025-12-18ORBIMED ADVISORS LLCdirectorSale100 @ $44.49$4K−0.0% of holding−9.4%−19.2%3,595,886Form 4 · filed 1 day after the trade
2025-12-17Thompson Peter A.directorSale900 @ $44.50$40K−0.0% of holding−8.4%−21.7%3,595,986Form 4 · filed 2 days after the trade
2025-12-17ORBIMED ADVISORS LLCdirectorSale900 @ $44.50$40K−0.0% of holding−8.4%−21.7%3,595,986Form 4 · filed 2 days after the trade
2025-12-05Fitzpatrick JenniferofficerSale10,250 @ $40.52$415K−100.0% of holding+6.4%−24.5%0Form 4 · filed 4 days after the trade
2025-11-26Thompson Peter A.directorSale1,600 @ $44.49$71K−0.0% of holding−3.7%−18.8%3,596,886Form 4 · filed same day
2025-11-26ORBIMED ADVISORS LLCdirectorSale1,600 @ $44.49$71K−0.0% of holding−3.7%−18.8%3,596,886Form 4 · filed same day
2025-11-25ORBIMED ADVISORS LLCdirectorSale11,890 @ $44.60$530K−0.3% of holding−3.9%−16.0%3,598,486Form 4 · filed 1 day after the trade
2025-11-25Thompson Peter A.directorSale11,890 @ $44.60$530K−0.3% of holding−3.9%−16.0%3,598,486Form 4 · filed 1 day after the trade
2025-11-24Thompson Peter A.directorSale94,583 @ $44.54$4.2M−2.6% of holding−4.3%−17.0%3,610,376Form 4 · filed 2 days after the trade
2025-11-24ORBIMED ADVISORS LLCdirectorSale94,583 @ $44.54$4.2M−2.6% of holding−4.3%−17.0%3,610,376Form 4 · filed 2 days after the trade
2025-11-21RA CAPITAL MANAGEMENT, L.P.directorSale9,924 @ $39.50$392K−1.5% of holding−5.2%−15.0%650,307Form 4 · filed 3 days after the trade
2025-11-21RA CAPITAL MANAGEMENT, L.P.directorSale7,609 @ $39.50$301K−4.6% of holding−5.2%−15.0%159,033Form 4 · filed 3 days after the trade
2025-11-21RA CAPITAL MANAGEMENT, L.P.directorSale6,440 @ $39.50$254K−0.3% of holding−5.2%−15.0%2,198,082Form 4 · filed 3 days after the trade
2025-11-21RA CAPITAL MANAGEMENT, L.P.directorSale1,210 @ $39.50$48K−0.0% of holding−5.2%−15.0%6,897,623Form 4 · filed 3 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale1,235 @ $39.89$49K−0.2% of holding+3.7%−5.6%661,019Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale947 @ $39.89$38K−0.6% of holding+3.7%−5.6%167,246Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale801 @ $39.89$32K−0.0% of holding+3.7%−5.6%2,205,034Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale788 @ $40.50$32K−0.1% of holding+3.7%−5.6%660,231Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale604 @ $40.50$24K−0.4% of holding+3.7%−5.6%166,642Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale512 @ $40.50$21K−0.0% of holding+3.7%−5.6%2,204,522Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale150 @ $39.89$6K−0.0% of holding+3.7%−5.6%6,898,929Form 4 · filed 4 days after the trade
2025-11-20RA CAPITAL MANAGEMENT, L.P.directorSale96 @ $40.50$4K−0.0% of holding+3.7%−5.6%6,898,833Form 4 · filed 4 days after the trade
2025-11-19RA CAPITAL MANAGEMENT, L.P.directorSale18,684 @ $40.01$748K−2.7% of holding+7.3%−6.1%662,266Form 4 · filed same day
2025-11-19RA CAPITAL MANAGEMENT, L.P.directorSale14,325 @ $40.01$573K−7.8% of holding+7.3%−6.1%168,202Form 4 · filed same day
2025-11-19RA CAPITAL MANAGEMENT, L.P.directorSale12,126 @ $40.01$485K−0.5% of holding+7.3%−6.1%2,205,843Form 4 · filed same day
2025-11-19RA CAPITAL MANAGEMENT, L.P.directorSale2,276 @ $40.01$91K−0.0% of holding+7.3%−6.1%6,899,081Form 4 · filed same day

The vs-S&P columns are a labeled look-back on what the stock did after each filing, measured against the index over the same window. Descriptive history, not a claim about the person or a reason to trade.

134 award / exercise / gift records — not counted as purchases

Awards, option exercises, gifts and tax-withholding disposals are shown separately and never counted as open-market purchases or sales — they carry no conviction information.

DatePersonRoleActionSharesOwned afterFiling
2026-07-06Fitzpatrick JenniferofficerOption exercise10,25010,250Form 4
2026-07-06Fitzpatrick JenniferofficerOption exercise10,25040,685Form 4
2026-06-17Fleming Harold EdwarddirectorAward / grant17,34017,340Form 4
2026-06-17Resnick JoshuadirectorAward / grant17,34017,340Form 4
2026-06-17RA CAPITAL MANAGEMENT, L.P.directorAward / grant17,34017,340Form 4
2026-06-17Viney Joanne L.directorAward / grant17,34017,340Form 4
2026-06-17Stelzer LauriedirectorAward / grant17,34017,340Form 4
2026-06-17Thompson Peter A.directorAward / grant17,34017,340Form 4
2026-06-17Ruddy Marcella K.directorAward / grant17,34017,340Form 4
2026-06-17Booth BrucedirectorAward / grant17,34017,340Form 4
2026-06-17Clancy Paul JdirectorAward / grant17,34017,340Form 4
2026-03-05Fitzpatrick JenniferofficerOption exercise10,25010,250Form 4
2026-03-05Fitzpatrick JenniferofficerOption exercise10,25050,935Form 4
2026-01-02McKee CharlotteofficerAward / grant155,700155,700Form 4
2026-01-02Fitzpatrick JenniferofficerAward / grant103,140103,140Form 4
2026-01-02Ridloff ElenadirectorAward / grant165,440165,440Form 4
2026-01-02Beer Caroline StarkofficerAward / grant139,340139,340Form 4
2026-01-02Cloonan MichaeldirectorAward / grant436,100436,100Form 4
2025-12-05Fitzpatrick JenniferofficerOption exercise10,25010,250Form 4
2025-12-05Fitzpatrick JenniferofficerOption exercise10,25061,185Form 4
2025-10-21Cloonan MichaeldirectorOption exercise33,532580,875Form 4
2025-10-21Cloonan MichaeldirectorOption exercise30,049577,392Form 4
2025-10-21Cloonan MichaeldirectorOption exercise22,895570,238Form 4
2025-10-21Cloonan MichaeldirectorOption exercise13,324560,667Form 4
2025-10-21Cloonan MichaeldirectorOption exercise33,53253,142Form 4
2025-10-21Cloonan MichaeldirectorOption exercise22,89586,674Form 4
2025-10-21Cloonan MichaeldirectorOption exercise13,324139,618Form 4
2025-10-21Cloonan MichaeldirectorOption exercise30,049109,569Form 4
2025-10-16Cloonan MichaeldirectorOption exercise10,225557,568Form 4
2025-10-16Cloonan MichaeldirectorOption exercise200547,543Form 4
2025-10-16Cloonan MichaeldirectorOption exercise200152,942Form 4
2025-10-16Cloonan MichaeldirectorOption exercise10,225153,142Form 4
2025-10-15Cloonan MichaeldirectorOption exercise14,775562,118Form 4
2025-10-15Cloonan MichaeldirectorOption exercise14,775163,367Form 4
2025-10-01Beer Caroline StarkofficerAward / grant255,000255,000Form 4
2025-09-29Cloonan MichaeldirectorOption exercise7,793555,136Form 4
2025-09-29Cloonan MichaeldirectorOption exercise7,793178,142Form 4
2025-09-26Cloonan MichaeldirectorOption exercise17,207564,550Form 4
2025-09-26Cloonan MichaeldirectorOption exercise17,207185,935Form 4
2025-09-04Fitzpatrick JenniferofficerOption exercise10,25010,250Form 4

Source: SEC Form 4 filings. Each row links to its original filing.

Across 2012–2021, stocks where a CEO, C-suite officer, or director had recently made an open-market common-stock purchase ran about +28 bp per month above the universe average (n=34,268 stock-weeks). A historical tendency, not a prediction.

Congressional disclosures

No congressional trades disclosed for this company.

Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.