Opaleye Management Inc.

Ten-percent owner · ACOG, SLGL, ETON, HROW, CDXS

As of 2026-09-16, Opaleye Management Inc. has 192 Form 4 transactions on record across 5 companies — 142 in the trailing 12 months.

Everything this person has disclosed to the SEC on Form 4 — across every company they file for — reconstructed from the public record. A filing history, not a tip sheet.

Pattern in the record: open-market purchases filed in August in multiple years since 2025 — a recurring calendar cadence, more consistent with scheduled activity than a one-off decision.

Reconstructed holdings

Direct: $0Indirect: $65.4M$65.4Mas of 2026-09-16
  • Direct $0
  • Indirect $65.4M
SLGLindirect540,000 sh$34.3M
ACOGindirect3,172,141 sh$26.6M
ETONindirect40,000 sh$2.3M
HROWindirect59,428 sh$2.0M
CDXSindirect179,989 sh$241K

Reconstructed from this person's own Form 4 filings — the total each filing reported owning afterward, priced at the close on the as-of date shown. A filed position can lag the real one.

Direct and indirect holdings (e.g. through a trust or fund) are tagged separately, as filed.

Trades by company

ACOG · 51 trades
2026-09-16: Purchase, 53,029 sh ($455K)2026-09-16: Purchase, 27,141 sh ($228K)2026-09-15: Purchase, 3,375 sh ($29K)2026-09-14: Purchase, 40,373 sh ($351K)2026-08-03: Purchase, 50,000 sh ($400K)2026-07-31: Purchase, 2,900 sh ($23K)2026-07-24: Purchase, 130 sh ($1K)2026-07-23: Purchase, 49,849 sh ($389K)2026-07-22: Purchase, 140,237 sh ($1.1M)2026-07-22: Purchase, 10,000 sh ($78K)2026-06-26: Purchase, 152,336 sh ($975K)2026-06-25: Purchase, 197 sh ($1K)2026-06-15: Purchase, 4,550 sh ($27K)2026-06-12: Purchase, 273 sh ($2K)2026-06-11: Purchase, 2,862 sh ($17K)2026-06-10: Purchase, 5,872 sh ($35K)2026-06-09: Purchase, 24,856 sh ($149K)2026-06-05: Purchase, 10,054 sh ($59K)2026-05-29: Purchase, 70,577 sh ($416K)2026-05-28: Purchase, 2,000 sh ($12K)2026-05-27: Purchase, 1,161 sh ($7K)2026-05-21: Purchase, 15,945 sh ($91K)2026-05-20: Purchase, 8,431 sh ($50K)2026-05-18: Purchase, 17,395 sh ($99K)2026-05-15: Purchase, 16,648 sh ($97K)2026-03-30: Purchase, 1,850 sh ($9K)2026-03-27: Purchase, 10,000 sh ($51K)2026-03-26: Purchase, 7,319 sh ($39K)2026-03-25: Purchase, 8,581 sh ($47K)2026-03-24: Purchase, 4,182 sh ($23K)2026-03-19: Purchase, 2,094 sh ($12K)2026-03-18: Purchase, 2,481 sh ($14K)2026-03-16: Purchase, 1,331 sh ($8K)2026-03-13: Purchase, 7,358 sh ($42K)2026-03-12: Purchase, 5,708 sh ($33K)2026-03-09: Purchase, 2,179 sh ($13K)2026-03-06: Purchase, 1,900 sh ($11K)2026-03-05: Purchase, 42,023 sh ($244K)2026-03-05: Purchase, 5,000 sh ($29K)2026-03-04: Purchase, 19,795 sh ($115K)2026-03-03: Purchase, 46,411 sh ($267K)2026-03-03: Purchase, 5,000 sh ($29K)2026-03-02: Purchase, 20,000 sh ($116K)2026-02-27: Purchase, 3,638 sh ($22K)2026-02-26: Purchase, 590 sh ($4K)2026-02-24: Purchase, 53,591 sh ($311K)2026-02-24: Purchase, 5,000 sh ($29K)2026-02-23: Purchase, 95,819 sh ($565K)2026-02-23: Purchase, 4,181 sh ($25K)2026-02-20: Purchase, 10,000 sh ($58K)2026-02-20: Purchase, 2,819 sh ($16K)
CDXS · 51 trades
2025-12-01: Sale, 245,000 sh ($409K)2025-12-01: Sale, 8,533 sh ($14K)2025-11-28: Sale, 105,000 sh ($184K)2025-11-28: Sale, 2,490 sh ($4K)2025-11-26: Sale, 148,318 sh ($258K)2025-11-26: Sale, 5,000 sh ($9K)2025-11-12: Sale, 890,000 sh ($1.7M)2025-11-12: Sale, 165,000 sh ($324K)2025-11-12: Sale, 27,459 sh ($53K)2025-11-11: Sale, 535,000 sh ($963K)2025-11-11: Sale, 13,211 sh ($24K)2025-11-10: Sale, 205,000 sh ($356K)2025-11-10: Sale, 3,318 sh ($6K)2025-11-07: Sale, 296,682 sh ($503K)2025-11-07: Sale, 10,000 sh ($17K)2025-08-04: Purchase, 780 sh ($2K)2025-07-31: Purchase, 84,220 sh ($226K)2025-07-30: Purchase, 1,578 sh ($4K)2025-07-29: Purchase, 8,422 sh ($24K)2025-07-18: Purchase, 100,000 sh ($282K)2025-06-27: Purchase, 100,000 sh ($239K)2025-06-16: Purchase, 50,898 sh ($114K)2025-06-13: Purchase, 99,102 sh ($221K)2025-06-12: Purchase, 100,000 sh ($225K)2025-05-28: Purchase, 5,000 sh ($12K)2025-05-23: Purchase, 2,320,000 sh ($5.5M)2025-05-01: Purchase, 20,000 sh ($46K)2025-04-30: Purchase, 25,000 sh ($58K)2025-04-25: Purchase, 25,000 sh ($56K)2025-04-17: Purchase, 45,000 sh ($94K)2025-04-16: Purchase, 70,000 sh ($149K)2025-04-15: Purchase, 25,000 sh ($56K)2025-04-08: Purchase, 100,000 sh ($198K)2025-04-03: Purchase, 75,000 sh ($173K)2025-04-02: Purchase, 5,000 sh ($12K)2025-04-01: Purchase, 35,000 sh ($87K)2025-03-21: Purchase, 92,923 sh ($236K)2025-03-20: Purchase, 7 sh ($18)2025-03-13: Purchase, 85,000 sh ($216K)2025-03-06: Purchase, 100,000 sh ($261K)2025-03-05: Purchase, 10,000 sh ($27K)2025-03-04: Purchase, 55,000 sh ($145K)2025-03-03: Purchase, 47,351 sh ($133K)2025-02-28: Purchase, 147,649 sh ($441K)2025-02-12: Purchase, 15,000 sh ($60K)2025-02-11: Purchase, 12,500 sh ($51K)2025-02-10: Purchase, 22,500 sh ($94K)2025-01-31: Purchase, 45,000 sh ($193K)2025-01-30: Purchase, 20,000 sh ($90K)2024-12-31: Purchase, 10,000 sh ($47K)2024-12-30: Purchase, 35,000 sh ($164K)
SLGL · 48 trades
2026-09-11: Purchase, 1,493 sh ($98K)2026-09-10: Purchase, 1,631 sh ($109K)2026-09-09: Purchase, 3,097 sh ($213K)2026-09-08: Purchase, 3,390 sh ($233K)2026-09-08: Purchase, 471 sh ($33K)2026-09-04: Purchase, 2,100 sh ($145K)2026-09-04: Purchase, 918 sh ($64K)2026-09-02: Purchase, 900 sh ($62K)2026-09-01: Purchase, 783 sh ($54K)2026-08-31: Purchase, 5,000 sh ($341K)2026-08-31: Purchase, 217 sh ($15K)2026-08-28: Purchase, 20,113 sh ($1.4M)2026-08-28: Purchase, 10,000 sh ($714K)2026-08-28: Purchase, 5,000 sh ($344K)2026-08-12: Purchase, 951 sh ($68K)2026-07-14: Purchase, 920 sh ($68K)2026-07-13: Purchase, 775 sh ($57K)2026-07-10: Purchase, 229 sh ($17K)2026-07-08: Purchase, 300 sh ($22K)2026-07-02: Purchase, 1,400 sh ($101K)2026-07-01: Purchase, 312 sh ($22K)2026-05-20: Purchase, 1,563 sh ($101K)2026-05-13: Purchase, 1,937 sh ($130K)2026-05-12: Purchase, 1,500 sh ($102K)2026-03-24: Purchase, 34,665 sh ($2.5M)2026-03-24: Purchase, 5,000 sh ($360K)2026-02-13: Purchase, 291 sh ($18K)2026-02-02: Purchase, 100 sh ($6K)2026-01-27: Purchase, 100 sh ($6K)2026-01-23: Purchase, 1,151 sh ($64K)2026-01-22: Purchase, 2,173 sh ($123K)2026-01-05: Purchase, 198 sh ($9K)2026-01-02: Purchase, 2,394 sh ($100K)2025-12-31: Purchase, 22,497 sh ($945K)2025-12-30: Purchase, 35,169 sh ($1.5M)2025-12-29: Purchase, 8,638 sh ($362K)2025-12-26: Purchase, 1,626 sh ($68K)2025-12-23: Purchase, 260 sh ($11K)2025-12-22: Purchase, 1,019 sh ($42K)2025-12-17: Purchase, 2,735 sh ($110K)2025-12-12: Purchase, 87 sh ($3K)2025-12-08: Purchase, 300 sh ($12K)2025-12-05: Purchase, 444 sh ($18K)2025-12-03: Purchase, 2,524 sh ($95K)2025-12-01: Purchase, 4,340 sh ($162K)2025-11-26: Purchase, 943 sh ($38K)2025-11-24: Purchase, 6 sh ($213)2025-11-20: Purchase, 5,784 sh ($207K)
HROW · 16 trades
2026-03-04: Sale, 134,000 sh ($5.3M)2026-03-04: Sale, 4,263 sh ($169K)2026-03-03: Sale, 59,000 sh ($2.3M)2026-03-03: Sale, 1,309 sh ($51K)2026-02-27: Sale, 5,000 sh ($271K)2026-01-06: Sale, 20,000 sh ($1.1M)2025-06-10: Sale, 15,000 sh ($462K)2025-06-09: Sale, 15,204 sh ($462K)2025-06-04: Sale, 1,796 sh ($54K)2025-06-03: Sale, 3,000 sh ($90K)2025-05-13: Sale, 5,000 sh ($133K)2025-05-12: Sale, 10,000 sh ($259K)2025-03-18: Sale, 5,000 sh ($150K)2025-03-18: Sale, 5,000 sh ($148K)2025-02-28: Sale, 5,000 sh ($140K)2025-01-22: Sale, 20,000 sh ($712K)
ETON · 9 trades
2026-07-14: Sale, 15,000 sh ($563K)2026-07-14: Sale, 13,315 sh ($500K)2026-07-07: Sale, 20,000 sh ($767K)2026-07-07: Sale, 6,685 sh ($257K)2026-07-06: Sale, 10,000 sh ($380K)2026-07-02: Sale, 65,000 sh ($2.4M)2026-07-02: Sale, 25,000 sh ($935K)2025-06-10: Purchase, 5,000 sh ($79K)2025-06-10: Purchase, 2,930 sh ($46K)

Filing ledger

DateCompanyActionShares @ priceValueOwnership ΔOwned afterFiling
2026-09-16ACOGPurchase53,029 @ $8.57$455K+1.7% of holding3,145,000Form 4
2026-09-16ACOGPurchase27,141 @ $8.40$228K+0.9% of holding3,172,141Form 4
2026-09-15ACOGPurchase3,375 @ $8.54$29K+0.1% of holding3,091,971Form 4
2026-09-14ACOGPurchase40,373 @ $8.70$351K+1.3% of holding3,088,596Form 4
2026-09-11SLGLPurchase1,493 @ $65.94$98K+0.3% of holding540,000Form 4
2026-09-10SLGLPurchase1,631 @ $66.80$109K+0.3% of holding538,507Form 4
2026-09-09SLGLPurchase3,097 @ $68.70$213K+0.6% of holding536,876Form 4
2026-09-09—Purchase5,836 @ $2.09$12K+0.2% of holding2,775,229Form 4
2026-09-08SLGLPurchase3,390 @ $68.74$233K+0.6% of holding533,308Form 4
2026-09-08SLGLPurchase471 @ $69.37$33K+0.1% of holding533,779Form 4
2026-09-08—Purchase9,393 @ $2.10$20K+0.3% of holding2,769,393Form 4
2026-09-04SLGLPurchase2,100 @ $68.98$145K+0.4% of holding529,918Form 4
2026-09-04SLGLPurchase918 @ $69.52$64K+0.2% of holding527,818Form 4
2026-09-02SLGLPurchase900 @ $68.95$62K+0.2% of holding526,900Form 4
2026-09-01SLGLPurchase783 @ $69.52$54K+0.1% of holding526,000Form 4
2026-08-31SLGLPurchase5,000 @ $68.23$341K+1.0% of holding525,000Form 4
2026-08-31SLGLPurchase217 @ $69.10$15K+0.0% of holding525,217Form 4
2026-08-28SLGLPurchase20,113 @ $68.42$1.4M+4.1% of holding515,000Form 4
2026-08-28SLGLPurchase10,000 @ $71.40$714K+2.1% of holding494,887Form 4
2026-08-28SLGLPurchase5,000 @ $68.81$344K+1.0% of holding520,000Form 4
2026-08-14—Purchase11,608 @ $2.09$24K+0.4% of holding2,760,000Form 4
2026-08-12SLGLPurchase951 @ $71.50$68K+0.2% of holding494,887Form 4
2026-08-03ACOGPurchase50,000 @ $8.00$400K+1.7% of holding3,048,223Form 4
2026-07-31ACOGPurchase2,900 @ $7.92$23K+0.1% of holding2,998,223Form 4
2026-07-24ACOGPurchase130 @ $7.90$1K+0.0% of holding2,995,323Form 4
2026-07-23ACOGPurchase49,849 @ $7.80$389K+1.7% of holding2,995,193Form 4
2026-07-22ACOGPurchase140,237 @ $7.83$1.1M+5.0% of holding2,945,344Form 4
2026-07-22ACOGPurchase10,000 @ $7.83$78K+11.1% of holding100,000Form 4
2026-07-14ETONSale15,000 @ $37.54$563K−0.6% of holding2,665,000Form 4
2026-07-14ETONSale13,315 @ $37.54$500K−25.0% of holding40,000Form 4
2026-07-14SLGLPurchase920 @ $73.43$68K+0.2% of holding493,936Form 4
2026-07-13SLGLPurchase775 @ $73.89$57K+0.2% of holding493,016Form 4
2026-07-10SLGLPurchase229 @ $73.95$17K+0.0% of holding492,241Form 4
2026-07-08SLGLPurchase300 @ $73.69$22K+0.1% of holding492,012Form 4
2026-07-07ETONSale20,000 @ $38.37$767K−0.7% of holding2,680,000Form 4
2026-07-07ETONSale6,685 @ $38.37$257K−11.1% of holding53,315Form 4
2026-07-06ETONSale10,000 @ $38.00$380K−0.4% of holding2,700,000Form 4
2026-07-02ETONSale65,000 @ $37.39$2.4M−2.3% of holding2,710,000Form 4
2026-07-02ETONSale25,000 @ $37.39$935K−29.4% of holding60,000Form 4
2026-07-02SLGLPurchase1,400 @ $71.97$101K+0.3% of holding491,712Form 4
2026-07-01SLGLPurchase312 @ $71.99$22K+0.1% of holding490,312Form 4
2026-06-26ACOGPurchase152,336 @ $6.40$975K+5.7% of holding2,805,107Form 4
2026-06-25ACOGPurchase197 @ $6.50$1K+0.0% of holding2,652,771Form 4
2026-06-15ACOGPurchase4,550 @ $5.99$27K+0.2% of holding2,652,574Form 4
2026-06-12ACOGPurchase273 @ $5.93$2K+0.0% of holding2,648,024Form 4
2026-06-11ACOGPurchase2,862 @ $5.91$17K+0.1% of holding2,647,751Form 4
2026-06-10ACOGPurchase5,872 @ $5.99$35K+0.2% of holding2,644,889Form 4
2026-06-09ACOGPurchase24,856 @ $5.98$149K+1.0% of holding2,639,017Form 4
2026-06-05ACOGPurchase10,054 @ $5.83$59K+0.4% of holding2,614,161Form 4
2026-05-29ACOGPurchase70,577 @ $5.90$416K+2.8% of holding2,604,107Form 4
2026-05-28ACOGPurchase2,000 @ $5.83$12K+0.1% of holding2,533,530Form 4
2026-05-27ACOGPurchase1,161 @ $5.73$7K+0.0% of holding2,531,530Form 4
2026-05-21ACOGPurchase15,945 @ $5.70$91K+0.6% of holding2,530,369Form 4
2026-05-20SLGLPurchase1,563 @ $64.43$101K+0.3% of holding490,000Form 4
2026-05-20ACOGPurchase8,431 @ $5.89$50K+0.3% of holding2,514,424Form 4
2026-05-18ACOGPurchase17,395 @ $5.69$99K+0.7% of holding2,505,993Form 4
2026-05-15ACOGPurchase16,648 @ $5.83$97K+0.7% of holding2,488,598Form 4
2026-05-13SLGLPurchase1,937 @ $66.87$130K+0.4% of holding488,437Form 4
2026-05-12SLGLPurchase1,500 @ $67.98$102K+0.3% of holding486,500Form 4
2026-05-01—Sale10,081 @ $16.11$162K−1.2% of holding853,569Form 4
2026-05-01—Sale500 @ $16.11$8K−9.1% of holding5,000Form 4
2026-04-30—Sale24,000 @ $16.15$388K−2.7% of holding863,650Form 4
2026-04-30—Sale1,000 @ $16.15$16K−15.4% of holding5,500Form 4
2026-04-29—Sale23,360 @ $17.25$403K−2.6% of holding887,650Form 4
2026-04-29—Sale1,000 @ $17.25$17K−13.3% of holding6,500Form 4
2026-04-28—Sale43,788 @ $18.47$809K−4.6% of holding911,010Form 4
2026-04-28—Sale2,500 @ $18.47$46K−25.0% of holding7,500Form 4
2026-04-21—Sale202 @ $20.50$4K−0.0% of holding954,798Form 4
2026-04-17—Sale11,267 @ $20.46$231K−1.2% of holding955,000Form 4
2026-04-17—Sale5,000 @ $20.46$102K−33.3% of holding10,000Form 4
2026-03-30ACOGPurchase1,850 @ $4.99$9K+0.1% of holding2,471,850Form 4
2026-03-27ACOGPurchase10,000 @ $5.08$51K+0.4% of holding2,470,000Form 4
2026-03-26ACOGPurchase7,319 @ $5.28$39K+0.3% of holding2,460,000Form 4
2026-03-25ACOGPurchase8,581 @ $5.43$47K+0.4% of holding2,452,681Form 4
2026-03-24SLGLPurchase34,665 @ $72.00$2.5M+7.7% of holding485,000Form 4
2026-03-24SLGLPurchase5,000 @ $72.00$360K+50.0% of holding15,000Form 4
2026-03-24ACOGPurchase4,182 @ $5.59$23K+0.2% of holding2,444,100Form 4
2026-03-19ACOGPurchase2,094 @ $5.71$12K+0.1% of holding2,439,918Form 4
2026-03-18ACOGPurchase2,481 @ $5.75$14K+0.1% of holding2,437,824Form 4
2026-03-16ACOGPurchase1,331 @ $5.78$8K+0.1% of holding2,435,343Form 4

Source: SEC Form 4 filings. Each row links to its original filing.

Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.