Issued 2026-09-25 at $85.69 · now $85.69 (2026-09-25, +0.0% since)
Based on its own history, a month from the 2026-09-25 close, SYRE has typically landed between $53.95 and $135.13 — a range of −37.0% to +57.7% from the issuance price $85.69.
- Actual close
- Typical path (median)
- Middle 50% of outcomes
- 90% range
2,608 overlapping 1 month windows · 2016-04-07 – 2026-08-26 · basis climatology · forecast (batch). Base rate up 53.7% (90% CI 51.5–55.9%, ≈1,391 obs). Not a call on this stock — we have no evidence its odds differ.
The cone is anchored at the 2026-09-25 issuance close ($85.69) — the price the forecast resolves against on 2026-10-26, not the latest close. The drawn path shape is illustrative (bands widen with √t); every labeled number is real — the anchor, the scored batch p90/IQR endpoints, and the typical move.
Where SYRE has typically landed a month from the 2026-09-25 close of $85.69 — the range is history, not a prediction.
- now $85.69 (+0.0%)
- typicalThe typical outcome — half of similar past periods did better and half did worse (not an average, so a few wild periods don't skew it). $84.59 (-1.3%)
- middle 50%The central range of outcomes — half of similar past periods landed inside it, a quarter finished above, a quarter below. $70.17–$99.01
- 90% rangeA nine-in-ten range — in about nine of every ten similar past periods the outcome stayed within these bounds. $53.95–$135.13
Actual 1-month windows behind the coneiEvery overlapping 1-month window in this security's own price history was ranked by realized return; shown are the 3 worst and 3 best of 2,608 windows spanning 2016-04-07 to 2026-09-25. Not cherry-picked — these are the extremes of the full sample. Max drop / max rise are the deepest and highest points reached within each window. See /methodology.
| Start | Return | Max drop | Max rise |
|---|---|---|---|
| 3 worst | |||
| 2022-11-10 | −74.7% | −75.6% | +0.0% |
| 2022-11-11 | −71.9% | −72.6% | +0.0% |
| 2022-11-16 | −71.9% | −71.9% | +0.0% |
| 3 best | |||
| 2023-06-21 | +456.6% | +0.0% | +538.5% |
| 2023-06-14 | +366.1% | −27.0% | +366.1% |
| 2023-06-15 | +334.8% | −28.0% | +359.8% |
2,608 overlapping windows · 2016-04-07 – 2026-09-25 · not cherry-picked
Pending catalysts
- 2026-10-31 — Trial primary completion: Phase 2 primary completion: A Study of SPY072 in Rheumatic Disease (source, as of 2026-08-14)
- June 2027 — Trial primary completion: Phase 2 primary completion: A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis (source, as of 2026-08-14)
- 2029-03-02 — Trial primary completion: Phase 2 primary completion: Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD (source, as of 2026-08-14)
Public, scheduled events — dated attention, not a prediction of the outcome. See the FDA catalysts page for the historical base rate.
Seasonality · by month iHow this security has tended to do in each calendar month historically — a frequency, never a prediction.
iFor each calendar month, the share of years this security closed higher than the month before, and the average month-over-month return, over ~11 years of its own price history. Cells are shaded by average return. This is historical frequency, not a prediction — no month is a signal.Jan
40%
+3.5%
n=10
Feb
50%
+2.9%
n=10
Mar
50%
+2.2%
n=10
Apr
20%
−1.0%
n=10
May
45%
−5.5%
n=11
Jun
45%
+12.7%
n=11
Jul
45%
+0.8%
n=11
Aug
73%
+9.1%
n=11
Sep
55%
+1.1%
n=11
Oct
40%
+10.9%
n=10
Nov
50%
+8.3%
n=10
Dec
30%
−9.1%
n=10
Up-frequency and average month-over-month return · historical frequency, not a prediction
Reported insider & political trades
Every Form 4 the people closest to this company have filed with the SEC — plotted against the share price, aggregated by month, and shown with the gap between when each trade happened and when it was disclosed. A public record, not advice.
| Date | Person | Role | Action | Shares @ price | Value | Ownership Δ | vs S&P 1m | vs S&P 6m | Owned after | Filing |
|---|---|---|---|---|---|---|---|---|---|---|
| 2026-09-02 | Burrows Scott L | officer | Sale | 18,232 @ $89.35 | $1.6M | −18.6% of holding | not yet — horizon still open | not yet — horizon still open | 79,762 | Form 4 · filed 1 day after the trade |
| 2026-09-02 | King-Jones Heidy | officer | Sale | 400 @ $90.00 | $36K | −12.3% of holding | not yet — horizon still open | not yet — horizon still open | 2,845 | Form 4 · filed 1 day after the trade |
| 2026-09-01 | King-Jones Heidy | officer | Sale | 16,548 @ $87.20 | $1.4M | −63.6% of holding | not yet — horizon still open | not yet — horizon still open | 9,451 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Turtle Cameron | director | Sale | 8,400 @ $87.15 | $732K | −1.5% of holding | not yet — horizon still open | not yet — horizon still open | 556,640 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | King-Jones Heidy | officer | Sale | 6,206 @ $88.17 | $547K | −65.7% of holding | not yet — horizon still open | not yet — horizon still open | 3,245 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | King-Jones Heidy | officer | Sale | 4,845 @ $86.40 | $419K | −15.7% of holding | not yet — horizon still open | not yet — horizon still open | 25,999 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Burrows Scott L | officer | Sale | 4,384 @ $87.11 | $382K | −4.2% of holding | not yet — horizon still open | not yet — horizon still open | 100,210 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Turtle Cameron | director | Sale | 3,700 @ $88.06 | $326K | −0.7% of holding | not yet — horizon still open | not yet — horizon still open | 552,940 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Turtle Cameron | director | Sale | 2,500 @ $86.36 | $216K | −0.4% of holding | not yet — horizon still open | not yet — horizon still open | 565,040 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Burrows Scott L | officer | Sale | 2,016 @ $88.03 | $177K | −2.0% of holding | not yet — horizon still open | not yet — horizon still open | 98,194 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Burrows Scott L | officer | Sale | 900 @ $86.25 | $78K | −0.9% of holding | not yet — horizon still open | not yet — horizon still open | 104,594 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | King-Jones Heidy | officer | Sale | 400 @ $89.38 | $36K | −12.3% of holding | not yet — horizon still open | not yet — horizon still open | 2,845 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Turtle Cameron | director | Sale | 400 @ $89.07 | $36K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 552,540 | Form 4 · filed 2 days after the trade |
| 2026-09-01 | Burrows Scott L | officer | Sale | 200 @ $89.04 | $18K | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 97,994 | Form 4 · filed 2 days after the trade |
| 2026-08-07 | Albers Jeffrey W. | director | Sale | 10,000 @ $104.68 | $1.0M | −51.7% of holding | −12.5% | not yet — horizon still open | 9,360 | Form 4 · filed 3 days after the trade |
| 2026-08-07 | Albers Jeffrey W. | director | Sale | 8,000 @ $104.38 | $835K | −29.2% of holding | −12.5% | not yet — horizon still open | 19,360 | Form 4 · filed 3 days after the trade |
| 2026-08-07 | Albers Jeffrey W. | director | Sale | 5,000 @ $104.47 | $522K | −100.0% of holding | −12.5% | not yet — horizon still open | 0 | Form 4 · filed 3 days after the trade |
| 2026-08-03 | Turtle Cameron | director | Sale | 7,157 @ $95.10 | $681K | −1.2% of holding | −7.3% | not yet — horizon still open | 574,583 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Turtle Cameron | director | Sale | 5,635 @ $95.93 | $541K | −1.0% of holding | −7.3% | not yet — horizon still open | 568,948 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Burrows Scott L | officer | Sale | 5,100 @ $95.21 | $486K | −4.8% of holding | −7.3% | not yet — horizon still open | 100,394 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Burrows Scott L | officer | Sale | 2,300 @ $96.30 | $221K | −2.3% of holding | −7.3% | not yet — horizon still open | 98,094 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Turtle Cameron | director | Sale | 1,392 @ $96.82 | $135K | −0.2% of holding | −7.3% | not yet — horizon still open | 567,556 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Turtle Cameron | director | Sale | 800 @ $93.97 | $75K | −0.1% of holding | −7.3% | not yet — horizon still open | 581,740 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Burrows Scott L | officer | Sale | 100 @ $97.10 | $10K | −0.1% of holding | −7.3% | not yet — horizon still open | 97,994 | Form 4 · filed 2 days after the trade |
| 2026-08-03 | Turtle Cameron | director | Sale | 16 @ $97.46 | $2K | −0.0% of holding | −7.3% | not yet — horizon still open | 567,540 | Form 4 · filed 2 days after the trade |
| 2026-07-01 | Turtle Cameron | director | Sale | 10,176 @ $87.44 | $890K | −1.7% of holding | +10.4% | not yet — horizon still open | 587,364 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Sloan Sheldon | officer | Sale | 6,500 @ $87.52 | $569K | −78.0% of holding | +10.4% | not yet — horizon still open | 1,834 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Burrows Scott L | officer | Sale | 5,775 @ $87.55 | $506K | −5.5% of holding | +10.4% | not yet — horizon still open | 99,719 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Turtle Cameron | director | Sale | 4,234 @ $88.12 | $373K | −0.7% of holding | +10.4% | not yet — horizon still open | 583,130 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Sloan Sheldon | officer | Sale | 1,834 @ $88.34 | $162K | −100.0% of holding | +10.4% | not yet — horizon still open | 0 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Burrows Scott L | officer | Sale | 1,725 @ $88.37 | $152K | −1.7% of holding | +10.4% | not yet — horizon still open | 97,994 | Form 4 · filed 1 day after the trade |
| 2026-07-01 | Turtle Cameron | director | Sale | 590 @ $88.91 | $52K | −0.1% of holding | +10.4% | not yet — horizon still open | 582,540 | Form 4 · filed 1 day after the trade |
| 2026-06-25 | Burrows Scott L | officer | Sale | 10,000 @ $87.14 | $871K | −9.3% of holding | +12.2% | not yet — horizon still open | 97,994 | Form 4 · filed 1 day after the trade |
| 2026-06-25 | Burrows Scott L | officer | Sale | 5,000 @ $87.12 | $436K | −4.4% of holding | +12.2% | not yet — horizon still open | 107,994 | Form 4 · filed 1 day after the trade |
| 2026-06-23 | Fairmount Funds Management LLC | director | Sale | 4,684,781 @ $85.31 | $399.7M | −100.0% of holding | +2.4% | not yet — horizon still open | 0 | Form 4 · filed same day |
| 2026-06-22 | HENDERSON MICHAEL THOMAS | director | Sale | 20,000 @ $100.00 | $2.0M | −22.6% of holding | −1.6% | not yet — horizon still open | 68,606 | Form 4 · filed 1 day after the trade |
| 2026-06-03 | Sloan Sheldon | officer | Sale | 8,333 @ $75.00 | $625K | −100.0% of holding | +20.8% | not yet — horizon still open | 0 | Form 4 · filed same day |
| 2026-06-01 | Turtle Cameron | director | Sale | 8,149 @ $70.50 | $575K | −1.3% of holding | +27.4% | not yet — horizon still open | 600,834 | Form 4 · filed 2 days after the trade |
| 2026-06-01 | Turtle Cameron | director | Sale | 3,557 @ $69.40 | $247K | −0.6% of holding | +27.4% | not yet — horizon still open | 608,983 | Form 4 · filed 2 days after the trade |
| 2026-06-01 | Turtle Cameron | director | Sale | 3,294 @ $71.38 | $235K | −0.5% of holding | +27.4% | not yet — horizon still open | 597,540 | Form 4 · filed 2 days after the trade |
| 2026-06-01 | Burrows Scott L | officer | Sale | 3,100 @ $72.06 | $223K | −3.1% of holding | +27.4% | not yet — horizon still open | 97,994 | Form 4 · filed 2 days after the trade |
| 2026-06-01 | Burrows Scott L | officer | Sale | 2,599 @ $70.77 | $184K | −2.5% of holding | +27.4% | not yet — horizon still open | 101,094 | Form 4 · filed 2 days after the trade |
| 2026-06-01 | Burrows Scott L | officer | Sale | 1,801 @ $69.75 | $126K | −1.7% of holding | +27.4% | not yet — horizon still open | 103,693 | Form 4 · filed 2 days after the trade |
| 2026-05-08 | HENDERSON MICHAEL THOMAS | director | Sale | 33,513 @ $73.72 | $2.5M | −20.2% of holding | +1.9% | not yet — horizon still open | 132,689 | Form 4 · filed same day |
| 2026-05-08 | HENDERSON MICHAEL THOMAS | director | Sale | 24,814 @ $74.76 | $1.9M | −18.7% of holding | +1.9% | not yet — horizon still open | 107,875 | Form 4 · filed same day |
| 2026-05-08 | HENDERSON MICHAEL THOMAS | director | Sale | 19,269 @ $75.35 | $1.5M | −17.9% of holding | +1.9% | not yet — horizon still open | 88,606 | Form 4 · filed same day |
| 2026-05-08 | HENDERSON MICHAEL THOMAS | director | Sale | 2,404 @ $72.57 | $174K | −1.4% of holding | +1.9% | not yet — horizon still open | 166,202 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 21,306 @ $69.53 | $1.5M | −27.2% of holding | −5.8% | not yet — horizon still open | 57,027 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 19,656 @ $70.61 | $1.4M | −34.5% of holding | −5.8% | not yet — horizon still open | 37,371 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 12,777 @ $72.94 | $932K | −44.7% of holding | −5.8% | not yet — horizon still open | 15,817 | Form 4 · filed same day |
| 2026-05-01 | Burrows Scott L | officer | Sale | 12,500 @ $71.37 | $892K | −11.3% of holding | −5.8% | not yet — horizon still open | 97,994 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 10,358 @ $73.74 | $764K | −65.5% of holding | −5.8% | not yet — horizon still open | 5,459 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 8,777 @ $71.56 | $628K | −23.5% of holding | −5.8% | not yet — horizon still open | 28,594 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 5,059 @ $74.60 | $377K | −92.7% of holding | −5.8% | not yet — horizon still open | 400 | Form 4 · filed same day |
| 2026-05-01 | Turtle Cameron | director | Sale | 5,300 @ $69.54 | $369K | −0.8% of holding | −5.8% | not yet — horizon still open | 622,240 | Form 4 · filed same day |
| 2026-05-01 | Turtle Cameron | director | Sale | 3,600 @ $70.77 | $255K | −0.6% of holding | −5.8% | not yet — horizon still open | 618,640 | Form 4 · filed same day |
| 2026-05-01 | Turtle Cameron | director | Sale | 3,100 @ $73.14 | $227K | −0.5% of holding | −5.8% | not yet — horizon still open | 614,540 | Form 4 · filed same day |
| 2026-05-01 | Turtle Cameron | director | Sale | 1,700 @ $74.23 | $126K | −0.3% of holding | −5.8% | not yet — horizon still open | 612,840 | Form 4 · filed same day |
| 2026-05-01 | Turtle Cameron | director | Sale | 1,000 @ $71.76 | $72K | −0.2% of holding | −5.8% | not yet — horizon still open | 617,640 | Form 4 · filed same day |
| 2026-05-01 | Sloan Sheldon | officer | Sale | 400 @ $75.37 | $30K | −100.0% of holding | −5.8% | not yet — horizon still open | 0 | Form 4 · filed same day |
The vs-S&P columns are a labeled look-back on what the stock did after each filing, measured against the index over the same window. Descriptive history, not a claim about the person or a reason to trade.
66 award / exercise / gift records — not counted as purchases
Awards, option exercises, gifts and tax-withholding disposals are shown separately and never counted as open-market purchases or sales — they carry no conviction information.
| Date | Person | Role | Action | Shares | Owned after | Filing |
|---|---|---|---|---|---|---|
| 2026-09-02 | King-Jones Heidy | officer | Option exercise | 400 | 3,245 | Form 4 |
| 2026-09-02 | King-Jones Heidy | officer | Option exercise | 400 | 511,411 | Form 4 |
| 2026-09-01 | King-Jones Heidy | officer | Option exercise | 27,999 | 30,844 | Form 4 |
| 2026-09-01 | Burrows Scott L | officer | Option exercise | 7,500 | 105,494 | Form 4 |
| 2026-09-01 | Burrows Scott L | officer | Option exercise | 7,500 | 337,357 | Form 4 |
| 2026-09-01 | King-Jones Heidy | officer | Option exercise | 27,999 | 511,811 | Form 4 |
| 2026-08-07 | Albers Jeffrey W. | director | Option exercise | 5,000 | 5,000 | Form 4 |
| 2026-08-07 | Albers Jeffrey W. | director | Option exercise | 5,000 | 45,000 | Form 4 |
| 2026-08-03 | Burrows Scott L | officer | Option exercise | 7,500 | 105,494 | Form 4 |
| 2026-08-03 | Burrows Scott L | officer | Option exercise | 7,500 | 344,857 | Form 4 |
| 2026-07-01 | Sloan Sheldon | officer | Option exercise | 8,334 | 8,334 | Form 4 |
| 2026-07-01 | Burrows Scott L | officer | Option exercise | 7,500 | 105,494 | Form 4 |
| 2026-07-01 | Sloan Sheldon | officer | Option exercise | 8,334 | 305,000 | Form 4 |
| 2026-07-01 | Burrows Scott L | officer | Option exercise | 7,500 | 352,357 | Form 4 |
| 2026-06-25 | Burrows Scott L | officer | Option exercise | 15,000 | 112,994 | Form 4 |
| 2026-06-25 | Burrows Scott L | officer | Option exercise | 15,000 | 359,857 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 16,667 | 0 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 666,680 | 4,684,781 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 666,680 | 4,684,781 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 666,680 | 4,684,781 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 666,680 | 4,684,781 | Form 4 |
| 2026-06-23 | Fairmount Funds Management LLC | director | Conversion | 666,680 | 4,684,781 | Form 4 |
| 2026-06-03 | Sloan Sheldon | officer | Option exercise | 8,333 | 8,333 | Form 4 |
| 2026-06-03 | Sloan Sheldon | officer | Option exercise | 8,333 | 313,334 | Form 4 |
| 2026-06-01 | Burrows Scott L | officer | Option exercise | 7,500 | 105,494 | Form 4 |
| 2026-06-01 | Burrows Scott L | officer | Option exercise | 7,500 | 374,857 | Form 4 |
| 2026-05-27 | McKenna Mark C. | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-27 | Stelzer Laurie | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-27 | Milligan Sandra | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-27 | HENDERSON MICHAEL THOMAS | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-27 | Fairmount Funds Management LLC | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-27 | Albers Jeffrey W. | director | Award / grant | 8,026 | 8,026 | Form 4 |
| 2026-05-01 | Sloan Sheldon | officer | Option exercise | 78,333 | 78,333 | Form 4 |
| 2026-05-01 | Burrows Scott L | officer | Option exercise | 12,500 | 110,494 | Form 4 |
| 2026-05-01 | Burrows Scott L | officer | Option exercise | 12,500 | 382,357 | Form 4 |
| 2026-05-01 | Sloan Sheldon | officer | Option exercise | 78,333 | 321,667 | Form 4 |
| 2026-04-01 | Sloan Sheldon | officer | Option exercise | 7,958 | 7,958 | Form 4 |
| 2026-04-01 | Burrows Scott L | officer | Option exercise | 7,500 | 105,494 | Form 4 |
| 2026-04-01 | Burrows Scott L | officer | Option exercise | 7,500 | 394,857 | Form 4 |
| 2026-04-01 | Sloan Sheldon | officer | Option exercise | 7,958 | 87,542 | Form 4 |
Source: SEC Form 4 filings. Each row links to its original filing.
Across 2012–2021, stocks where a CEO, C-suite officer, or director had recently made an open-market common-stock purchase ran about +28 bp per month above the universe average (n=34,268 stock-weeks). A historical tendency, not a prediction.
Congressional disclosures
No congressional trades disclosed for this company.
Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.