OPKOPKO Health, Inc.Healthcare · Biotechnologyas of 2026-09-25
Horizon

Issued 2026-09-25 at $1.64 · now $1.64 (2026-09-25, +0.0% since)

Based on its own history, a month from the 2026-09-25 close, OPK has typically landed between $1.27 and $2.08 — a range of −22.5% to +26.9% from the issuance price $1.64.

Range of outcomes in historically similar periods — not a price prediction. Ranges are scored publicly on /methodology.
  • Actual close
  • Typical path (median)
  • Middle 50% of outcomes
  • 90% range

5,010 overlapping 1 month windows · 2006-09-26 – 2026-08-26 · basis climatology · forecast (batch). Base rate up 53.7% (90% CI 51.5–55.9%, ≈1,391 obs). Not a call on this stock — we have no evidence its odds differ.

The cone is anchored at the 2026-09-25 issuance close ($1.64) — the price the forecast resolves against on 2026-10-26, not the latest close. The drawn path shape is illustrative (bands widen with √t); every labeled number is real — the anchor, the scored batch p90/IQR endpoints, and the typical move.

Where OPK has typically landed a month from the 2026-09-25 close of $1.64 — the range is history, not a prediction.

$1.27worst · -22.5%$2.08best · +26.9%
  • now $1.64 (+0.0%)
  • typicalThe typical outcome — half of similar past periods did better and half did worse (not an average, so a few wild periods don't skew it). $1.63 (-0.8%)
  • middle 50%The central range of outcomes — half of similar past periods landed inside it, a quarter finished above, a quarter below. $1.48–$1.78
  • 90% rangeA nine-in-ten range — in about nine of every ten similar past periods the outcome stayed within these bounds. $1.27–$2.08
Actual 1-month windows behind the coneiEvery overlapping 1-month window in this security's own price history was ranked by realized return; shown are the 3 worst and 3 best of 5,010 windows spanning 2006-09-26 to 2026-09-25. Not cherry-picked — these are the extremes of the full sample. Max drop / max rise are the deepest and highest points reached within each window. See /methodology.
StartReturnMax dropMax rise
3 worst
2009-02-09−52.8%−52.8%+0.0%
2009-02-11−50.8%−51.6%+2.4%
2009-02-13−48.8%−52.0%+0.0%
3 best
2020-06-19+150.4%+0.0%+150.4%
2007-03-14+128.6%+0.0%+128.6%
2020-06-25+118.3%+0.0%+122.4%

5,010 overlapping windows · 2006-09-26 – 2026-09-25 · not cherry-picked

Pending catalysts

  • December 2027 — Trial primary completion: Phase 1/Phase PHASE2 primary completion: Phase 1/2 Study of OPK-88006 in Healthy and Presumed MASH Participants (source, as of 2026-08-14)

Public, scheduled events — dated attention, not a prediction of the outcome. See the FDA catalysts page for the historical base rate.

Seasonality · by month iHow this security has tended to do in each calendar month historically — a frequency, never a prediction.

iFor each calendar month, the share of years this security closed higher than the month before, and the average month-over-month return, over ~20 years of its own price history. Cells are shaded by average return. This is historical frequency, not a prediction — no month is a signal.
Jan
50%
+3.3%
n=20
Feb
45%
+2.7%
n=20
Mar
35%
+2.4%
n=20
Apr
45%
+1.6%
n=20
May
45%
+3.2%
n=20
Jun
55%
+7.7%
n=20
Jul
55%
+5.9%
n=20
Aug
50%
−1.2%
n=20
Sep
40%
−2.8%
n=20
Oct
50%
−0.6%
n=20
Nov
70%
+1.5%
n=20
Dec
35%
−2.3%
n=20

Up-frequency and average month-over-month return · historical frequency, not a prediction

Reported insider & political trades

Every Form 4 the people closest to this company have filed with the SEC — plotted against the share price, aggregated by month, and shown with the gap between when each trade happened and when it was disclosed. A public record, not advice.

Share price & reported tradesMonthly open-market valueReporting lag — trade date to filing date2026-092026-082026-072026-062026-052026-042026-032026-022026-012025-122025-112025-102025-092025-08$2$12026-03-20: 1 insider purchase, $11K — PAGANELLI JOHN A2025-11-21: 5 insider purchases, $769K — FROST PHILLIP MD ET AL …2025-11-20: 7 insider purchases, $771K — FROST PHILLIP MD ET AL …2025-11-19: 9 insider purchases, $759K — FROST PHILLIP MD ET AL …2025-11-18: 11 insider purchases, $679K — FROST PHILLIP MD ET AL …2025-10-31: 1 insider purchase, $213K — FROST PHILLIP MD ET AL2025-08: 1 open-market purchase, $891K2025-10: 1 open-market purchase, $213K2025-11: 32 open-market purchases, $3.0M2026-03: 1 open-market purchase, $11K↑ buys↓ salesdirector PAGANELLI JOHN A — Purchase on 2026-03-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-21, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-21, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-21, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-21, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-21, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-20, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-19, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-11-18, filed same daydirector FROST PHILLIP MD ET AL — Purchase on 2025-10-31, filed same day
DatePersonRoleActionShares @ priceValueOwnership Δvs S&P 1mvs S&P 6mOwned afterFiling
2026-03-20PAGANELLI JOHN AdirectorPurchase10,000 @ $1.14$11K+2.6% of holding+0.4%+31.3%394,340Form 4 · filed same day
2025-11-21FROST PHILLIP MD ET ALdirectorPurchase192,870 @ $1.33$257K+0.1% of holding−5.5%−16.0%216,706,448Form 4 · filed same day
2025-11-21FROST PHILLIP MD ET ALdirectorPurchase191,490 @ $1.33$255K+0.1% of holding−5.5%−16.0%216,513,578Form 4 · filed same day
2025-11-21FROST PHILLIP MD ET ALdirectorPurchase102,371 @ $1.30$133K+0.0% of holding−5.5%−16.0%216,228,819Form 4 · filed same day
2025-11-21FROST PHILLIP MD ET ALdirectorPurchase89,375 @ $1.32$118K+0.0% of holding−5.5%−16.0%216,322,088Form 4 · filed same day
2025-11-21FROST PHILLIP MD ET ALdirectorPurchase3,894 @ $1.32$5K+0.0% of holding−5.5%−16.0%216,232,713Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase211,948 @ $1.33$282K+0.1% of holding−3.0%−16.4%215,924,630Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase161,818 @ $1.33$216K+0.1% of holding−3.0%−16.4%216,086,448Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase119,129 @ $1.32$157K+0.1% of holding−3.0%−16.4%215,665,577Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase47,105 @ $1.32$62K+0.0% of holding−3.0%−16.4%215,712,682Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase24,579 @ $1.34$33K+0.0% of holding−3.0%−16.4%216,111,027Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase13,664 @ $1.35$18K+0.0% of holding−3.0%−16.4%216,126,448Form 4 · filed same day
2025-11-20FROST PHILLIP MD ET ALdirectorPurchase1,757 @ $1.34$2K+0.0% of holding−3.0%−16.4%216,112,784Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase198,904 @ $1.31$262K+0.1% of holding−3.0%−16.2%215,390,952Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase155,496 @ $1.32$205K+0.1% of holding−3.0%−16.2%215,546,448Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase66,504 @ $1.31$87K+0.0% of holding−3.0%−16.2%215,192,048Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase58,160 @ $1.28$75K+0.0% of holding−3.0%−16.2%215,060,933Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase36,325 @ $1.28$46K+0.0% of holding−3.0%−16.2%215,002,773Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase30,082 @ $1.30$39K+0.0% of holding−3.0%−16.2%215,112,551Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase21,236 @ $1.29$28K+0.0% of holding−3.0%−16.2%215,082,469Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase12,993 @ $1.30$17K+0.0% of holding−3.0%−16.2%215,125,544Form 4 · filed same day
2025-11-19FROST PHILLIP MD ET ALdirectorPurchase300 @ $1.29$387+0.0% of holding−3.0%−16.2%215,061,233Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase212,608 @ $1.27$271K+0.1% of holding−0.1%−13.2%214,779,163Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase83,556 @ $1.28$107K+0.0% of holding−0.1%−13.2%214,932,875Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase69,728 @ $1.28$89K+0.0% of holding−0.1%−13.2%214,848,891Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase66,635 @ $1.25$84K+0.0% of holding−0.1%−13.2%214,503,083Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase49,590 @ $1.25$62K+0.0% of holding−0.1%−13.2%214,436,448Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase33,572 @ $1.29$43K+0.0% of holding−0.1%−13.2%214,966,448Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase15,000 @ $1.26$19K+0.0% of holding−0.1%−13.2%214,564,783Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase1,772 @ $1.27$2K+0.0% of holding−0.1%−13.2%214,566,555Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase428 @ $1.28$550+0.0% of holding−0.1%−13.2%214,849,319Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase410 @ $1.25$510+0.0% of holding−0.1%−13.2%214,386,858Form 4 · filed same day
2025-11-18FROST PHILLIP MD ET ALdirectorPurchase1 @ $1.29$1+0.0% of holding−0.1%−13.2%214,932,876Form 4 · filed same day
2025-10-31FROST PHILLIP MD ET ALdirectorPurchase150,000 @ $1.42$213K+0.1% of holding−2.1%−23.6%214,386,448Form 4 · filed same day
2025-08-08FROST PHILLIP MD ET ALdirectorPurchase675,000 @ $1.32$891K+0.3% of holding+10.7%−11.9%214,676,448Form 4 · filed same day
2025-04-10FROST PHILLIP MD ET ALdirectorPurchase125,000 @ $1.36$170K+0.1% of holding−18.5%−14.2%214,001,448Form 4 · filed same day
2025-04-08FROST PHILLIP MD ET ALdirectorPurchase125,000 @ $1.48$185K+0.1% of holding−27.5%−30.2%213,876,448Form 4 · filed same day
2025-04-01FROST PHILLIP MD ET ALdirectorPurchase100,000 @ $1.65$165K+0.0% of holding−18.2%−26.5%213,751,448Form 4 · filed same day
2025-03-28FROST PHILLIP MD ET ALdirectorPurchase150,000 @ $1.70$254K+0.1% of holding−17.4%−33.7%213,651,448Form 4 · filed same day
2025-03-17FROST PHILLIP MD ET ALdirectorPurchase200,000 @ $1.74$348K+0.1% of holding−15.5%−40.3%213,501,448Form 4 · filed same day
2025-03-04FROST PHILLIP MD ET ALdirectorPurchase— @ $436500.00—ownership Δ n/a−12.2%−40.4%—Form 4 · filed same day
2025-03-04FROST PHILLIP MD ET ALdirectorPurchase— @ $436500.00—ownership Δ n/a−12.2%−40.4%—Form 4 · filed same day
2025-03-04FROST PHILLIP MD ET ALdirectorPurchase— @ $436500.00—ownership Δ n/a−12.2%−40.4%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1703250.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1703250.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1707125.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1707125.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1703250.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-03-03FROST PHILLIP MD ET ALdirectorPurchase— @ $1707125.00—ownership Δ n/a−1.5%−32.6%—Form 4 · filed same day
2025-02-28FROST PHILLIP MD ET ALdirectorPurchase67,434 @ $1.71$115K+0.0% of holding+1.0%−29.9%213,301,448Form 4 · filed same day
2025-02-28FROST PHILLIP MD ET ALdirectorPurchase— @ $1652750.00—ownership Δ n/a+1.0%−29.9%—Form 4 · filed same day
2025-02-28FROST PHILLIP MD ET ALdirectorPurchase— @ $1652750.00—ownership Δ n/a+1.0%−29.9%—Form 4 · filed same day
2025-02-28FROST PHILLIP MD ET ALdirectorPurchase— @ $1652750.00—ownership Δ n/a+1.0%−29.9%—Form 4 · filed same day
2025-01-28FROST PHILLIP MD ET ALdirectorPurchase47,537 @ $1.47$70K+0.0% of holding+11.9%−16.2%213,234,014Form 4 · filed same day
2025-01-17FROST PHILLIP MD ET ALdirectorPurchase150,000 @ $1.47$220K+0.1% of holding+13.8%−12.0%213,186,477Form 4 · filed same day
2025-01-15FROST PHILLIP MD ET ALdirectorPurchase500,000 @ $1.48$741K+0.2% of holding+8.7%−14.7%213,036,477Form 4 · filed same day
2024-12-13FROST PHILLIP MD ET ALdirectorPurchase125,000 @ $1.59$199K+0.1% of holding−5.8%−18.4%212,536,477Form 4 · filed same day
2024-12-11FROST PHILLIP MD ET ALdirectorPurchase500,000 @ $1.56$781K+0.2% of holding−3.1%−16.2%212,411,477Form 4 · filed same day
2024-11-29FROST PHILLIP MD ET ALdirectorPurchase199,072 @ $1.53$305K+0.1% of holding−2.1%−11.9%211,911,477Form 4 · filed same day
2024-11-22FROST PHILLIP MD ET ALdirectorPurchase100,000 @ $1.59$159K+0.0% of holding−5.7%−13.6%211,712,405Form 4 · filed same day

The vs-S&P columns are a labeled look-back on what the stock did after each filing, measured against the index over the same window. Descriptive history, not a claim about the person or a reason to trade.

29 award / exercise / gift records — not counted as purchases

Awards, option exercises, gifts and tax-withholding disposals are shown separately and never counted as open-market purchases or sales — they carry no conviction information.

DatePersonRoleActionSharesOwned afterFiling
2026-07-24Rubin Steven DdirectorWithheld for tax53,2666,571,966Form 4
2026-07-24Logal AdamofficerWithheld for tax53,266563,396Form 4
2026-06-18MEDEL ROGER MDdirectorAward / grant30,00030,000Form 4
2026-06-18Yu Alice Lin-TsingdirectorAward / grant30,00030,000Form 4
2026-06-18UPPALURI SUBBARAO VdirectorAward / grant80,00080,000Form 4
2026-06-18PAGANELLI JOHN AdirectorAward / grant30,00030,000Form 4
2026-06-18PFENNIGER RICHARD C JRdirectorAward / grant60,00060,000Form 4
2026-06-18Lachman Prem AdirectorAward / grant30,00030,000Form 4
2026-03-18UPPALURI SUBBARAO VdirectorAward / grant50,00050,000Form 4
2025-11-18FROST PHILLIP MD ET ALdirectorAward / grant46,700214,549,783Form 4
2025-08-18FROST PHILLIP MD ET ALdirectorGift440,000214,236,448Form 4
2025-05-27HSIAO JANE PH DdirectorAward / grant500,000500,000Form 4
2025-05-27FROST PHILLIP MD ET ALdirectorAward / grant500,000500,000Form 4
2025-05-27Rubin Steven DdirectorAward / grant437,500437,500Form 4
2025-05-27Zerhouni Elias A.directorAward / grant500,000500,000Form 4
2025-05-27Nabel Gary J.directorAward / grant437,500437,500Form 4
2025-05-27Logal AdamofficerAward / grant437,500437,500Form 4
2025-04-23KRASNO RICHARD MdirectorAward / grant30,00030,000Form 4
2025-04-23Yu Alice Lin-TsingdirectorAward / grant30,00030,000Form 4
2025-04-23Lachman Prem AdirectorAward / grant30,00030,000Form 4
2025-04-23MEDEL ROGER MDdirectorAward / grant30,00030,000Form 4
2025-04-23PFENNIGER RICHARD C JRdirectorAward / grant60,00060,000Form 4
2025-04-23PAGANELLI JOHN AdirectorAward / grant30,00030,000Form 4
2024-07-24Nabel Gary J.directorAward / grant437,500700,579Form 4
2024-07-24FROST PHILLIP MD ET ALdirectorAward / grant500,0003,568,951Form 4
2024-07-24HSIAO JANE PH DdirectorAward / grant500,00028,499,880Form 4
2024-07-24Logal AdamofficerAward / grant437,500616,662Form 4
2024-07-24Zerhouni Elias A.directorAward / grant500,000589,600Form 4
2024-07-24Rubin Steven DdirectorAward / grant437,5006,625,232Form 4

Source: SEC Form 4 filings. Each row links to its original filing.

Across 2012–2021, stocks where a CEO, C-suite officer, or director had recently made an open-market common-stock purchase ran about +28 bp per month above the universe average (n=34,268 stock-weeks). A historical tendency, not a prediction.

Congressional disclosures

No congressional trades disclosed for this company.

Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.