Issued 2026-09-25 at $345.82 · now $345.82 (2026-09-25, +0.0% since)
Based on its own history, a month from the 2026-09-25 close, KRYS has typically landed between $289.73 and $421.90 — a range of −16.2% to +22.0% from the issuance price $345.82.
- Actual close
- Typical path (median)
- Middle 50% of outcomes
- 90% range
2,244 overlapping 1 month windows · 2017-09-20 – 2026-08-26 · basis climatology · forecast (batch). Base rate up 53.7% (90% CI 51.5–55.9%, ≈1,391 obs). Not a call on this stock — we have no evidence its odds differ.
The cone is anchored at the 2026-09-25 issuance close ($345.82) — the price the forecast resolves against on 2026-10-26, not the latest close. The drawn path shape is illustrative (bands widen with √t); every labeled number is real — the anchor, the scored batch p90/IQR endpoints, and the typical move.
Where KRYS has typically landed a month from the 2026-09-25 close of $345.82 — the range is history, not a prediction.
- now $345.82 (+0.0%)
- typicalThe typical outcome — half of similar past periods did better and half did worse (not an average, so a few wild periods don't skew it). $354.23 (+2.4%)
- middle 50%The central range of outcomes — half of similar past periods landed inside it, a quarter finished above, a quarter below. $326.69–$381.77
- 90% rangeA nine-in-ten range — in about nine of every ten similar past periods the outcome stayed within these bounds. $289.73–$421.9
Actual 1-month windows behind the coneiEvery overlapping 1-month window in this security's own price history was ranked by realized return; shown are the 3 worst and 3 best of 2,244 windows spanning 2017-09-20 to 2026-09-25. Not cherry-picked — these are the extremes of the full sample. Max drop / max rise are the deepest and highest points reached within each window. See /methodology.
| Start | Return | Max drop | Max rise |
|---|---|---|---|
| 3 worst | |||
| 2020-02-18 | −43.7% | −43.7% | +0.8% |
| 2020-02-13 | −40.7% | −40.7% | +0.0% |
| 2020-02-11 | −39.3% | −39.3% | +3.5% |
| 3 best | |||
| 2021-11-26 | +77.7% | +0.0% | +102.3% |
| 2019-06-20 | +77.4% | +0.0% | +77.4% |
| 2019-06-14 | +75.3% | +0.0% | +75.3% |
2,244 overlapping windows · 2017-09-20 – 2026-09-25 · not cherry-picked
Pending catalysts
- December 2026 — Trial primary completion: Phase 3 primary completion: A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa (source, as of 2026-08-14)
- December 2026 — Trial primary completion: Phase 1/Phase PHASE2 primary completion: A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis (source, as of 2026-08-14)
- February 2027 — Trial primary completion: Phase 1/Phase PHASE2 primary completion: A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs (source, as of 2026-08-14)
- July 2027 — Trial primary completion: Phase 1/Phase PHASE2 primary completion: A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors (source, as of 2026-08-14)
Public, scheduled events — dated attention, not a prediction of the outcome. See the FDA catalysts page for the historical base rate.
Seasonality · by month iHow this security has tended to do in each calendar month historically — a frequency, never a prediction.
iFor each calendar month, the share of years this security closed higher than the month before, and the average month-over-month return, over ~9 years of its own price history. Cells are shaded by average return. This is historical frequency, not a prediction — no month is a signal.Jan
56%
+1.2%
n=9
Feb
67%
+8.2%
n=9
Mar
56%
+3.8%
n=9
Apr
44%
−1.7%
n=9
May
56%
+3.1%
n=9
Jun
78%
+12.5%
n=9
Jul
67%
+5.9%
n=9
Aug
22%
−0.4%
n=9
Sep
22%
−3.8%
n=9
Oct
56%
+5.3%
n=9
Nov
89%
+19.0%
n=9
Dec
56%
−1.2%
n=9
Up-frequency and average month-over-month return · historical frequency, not a prediction
Reported insider & political trades
Every Form 4 the people closest to this company have filed with the SEC — plotted against the share price, aggregated by month, and shown with the gap between when each trade happened and when it was disclosed. A public record, not advice.
| Date | Person | Role | Action | Shares @ price | Value | Ownership Δ | vs S&P 1m | vs S&P 6m | Owned after | Filing |
|---|---|---|---|---|---|---|---|---|---|---|
| 2026-09-04 | Krishnan Krish S | director | Sale | 3,981 @ $357.57 | $1.4M | −0.3% of holding | not yet — horizon still open | not yet — horizon still open | 1,362,716 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 3,962 @ $357.57 | $1.4M | −0.3% of holding | not yet — horizon still open | not yet — horizon still open | 1,317,390 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 3,392 @ $359.39 | $1.2M | −0.3% of holding | not yet — horizon still open | not yet — horizon still open | 1,310,818 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 3,357 @ $359.39 | $1.2M | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,356,216 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 3,297 @ $356.37 | $1.2M | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,366,697 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 3,267 @ $356.37 | $1.2M | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,321,352 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 3,180 @ $358.42 | $1.1M | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,314,210 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 3,143 @ $358.42 | $1.1M | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,359,573 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 2,320 @ $360.47 | $836K | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,308,498 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 2,266 @ $360.46 | $817K | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,353,950 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 2,010 @ $362.65 | $729K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,350,726 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 1,992 @ $362.65 | $722K | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,305,264 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 2,029 @ $355.57 | $721K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,369,994 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 2,006 @ $355.57 | $713K | −0.2% of holding | not yet — horizon still open | not yet — horizon still open | 1,324,619 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 1,358 @ $364.48 | $495K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,348,795 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 1,329 @ $364.48 | $484K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,303,370 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 1,242 @ $361.61 | $449K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,307,256 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 1,214 @ $361.61 | $439K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,352,736 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 847 @ $365.42 | $310K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,347,948 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 826 @ $365.41 | $302K | −0.1% of holding | not yet — horizon still open | not yet — horizon still open | 1,302,544 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 573 @ $363.34 | $208K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,350,153 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 565 @ $363.34 | $205K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,304,699 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 520 @ $354.54 | $184K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,326,625 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 520 @ $354.54 | $184K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,372,023 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Krish S | director | Sale | 405 @ $366.56 | $148K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,347,543 | Form 4 · filed same day |
| 2026-09-04 | Krishnan Suma | director | Sale | 399 @ $366.56 | $146K | −0.0% of holding | not yet — horizon still open | not yet — horizon still open | 1,302,145 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 7,428 @ $329.60 | $2.4M | −11.3% of holding | +4.0% | not yet — horizon still open | 58,031 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 5,226 @ $327.39 | $1.7M | −7.2% of holding | +4.0% | not yet — horizon still open | 67,146 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 4,896 @ $330.36 | $1.6M | −8.4% of holding | +4.0% | not yet — horizon still open | 53,135 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 3,095 @ $331.43 | $1.0M | −5.8% of holding | +4.0% | not yet — horizon still open | 50,040 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 2,287 @ $326.60 | $747K | −3.1% of holding | +4.0% | not yet — horizon still open | 72,372 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 1,687 @ $328.52 | $554K | −2.5% of holding | +4.0% | not yet — horizon still open | 65,459 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 341 @ $325.60 | $111K | −0.5% of holding | +4.0% | not yet — horizon still open | 74,659 | Form 4 · filed same day |
| 2026-08-14 | ROSSI DINO A | director | Sale | 40 @ $333.23 | $13K | −0.1% of holding | +4.0% | not yet — horizon still open | 50,000 | Form 4 · filed same day |
| 2026-06-25 | Thomas John Charles | officer | Sale | 1,000 @ $347.27 | $347K | −100.0% of holding | −2.9% | not yet — horizon still open | 0 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 12,729 @ $307.81 | $3.9M | −0.9% of holding | +20.7% | not yet — horizon still open | 1,387,038 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 11,461 @ $307.68 | $3.5M | −0.8% of holding | +20.7% | not yet — horizon still open | 1,461,523 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 4,830 @ $308.47 | $1.5M | −0.3% of holding | +20.7% | not yet — horizon still open | 1,456,693 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 3,803 @ $308.89 | $1.2M | −0.3% of holding | +20.7% | not yet — horizon still open | 1,383,235 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 2,801 @ $309.95 | $868K | −0.2% of holding | +20.7% | not yet — horizon still open | 1,380,434 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 2,784 @ $309.49 | $862K | −0.2% of holding | +20.7% | not yet — horizon still open | 1,453,909 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 2,652 @ $310.43 | $823K | −0.2% of holding | +20.7% | not yet — horizon still open | 1,451,257 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 2,039 @ $310.94 | $634K | −0.1% of holding | +20.7% | not yet — horizon still open | 1,378,395 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 1,348 @ $307.09 | $414K | −0.1% of holding | +20.7% | not yet — horizon still open | 1,399,767 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 964 @ $311.36 | $300K | −0.1% of holding | +20.7% | not yet — horizon still open | 1,450,293 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 640 @ $302.24 | $193K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,474,293 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 589 @ $306.33 | $180K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,472,984 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 593 @ $302.25 | $179K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,402,242 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 544 @ $304.81 | $166K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,473,573 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 480 @ $305.87 | $147K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,401,115 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 400 @ $304.89 | $122K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,401,595 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 320 @ $300.75 | $96K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,474,933 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 320 @ $300.75 | $96K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,402,835 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 247 @ $303.17 | $75K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,401,995 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Suma | director | Sale | 240 @ $311.65 | $75K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,378,155 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 176 @ $303.17 | $53K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,474,117 | Form 4 · filed 1 day after the trade |
| 2026-06-04 | Krishnan Krish S | director | Sale | 40 @ $312.23 | $12K | −0.0% of holding | +20.7% | not yet — horizon still open | 1,450,253 | Form 4 · filed 1 day after the trade |
| 2026-05-26 | Thomas John Charles | officer | Sale | 642 @ $302.03 | $194K | −100.0% of holding | +20.8% | not yet — horizon still open | 0 | Form 4 · filed 1 day after the trade |
| 2026-03-04 | Krishnan Krish S | director | Sale | 8,798 @ $264.85 | $2.3M | −0.6% of holding | +2.5% | +27.1% | 1,478,612 | Form 4 · filed 2 days after the trade |
| 2026-03-04 | Krishnan Suma | director | Sale | 6,000 @ $265.16 | $1.6M | −0.4% of holding | +2.5% | +27.1% | 1,404,855 | Form 4 · filed 2 days after the trade |
The vs-S&P columns are a labeled look-back on what the stock did after each filing, measured against the index over the same window. Descriptive history, not a claim about the person or a reason to trade.
107 award / exercise / gift records — not counted as purchases
Awards, option exercises, gifts and tax-withholding disposals are shown separately and never counted as open-market purchases or sales — they carry no conviction information.
| Date | Person | Role | Action | Shares | Owned after | Filing |
|---|---|---|---|---|---|---|
| 2026-09-14 | Sutherland Everett Rand | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | ROSSI DINO A | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | Mason Christopher | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-09-14 | Mason Christopher | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | Sutherland Everett Rand | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-09-14 | Gangolli Julian S | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-09-14 | Gangolli Julian S | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | JANNEY DANIEL | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-09-14 | JANNEY DANIEL | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | Mazzacco Catherine | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-09-14 | Mazzacco Catherine | director | Award / grant | 471 | 471 | Form 4 |
| 2026-09-14 | ROSSI DINO A | director | Award / grant | 1,187 | 1,187 | Form 4 |
| 2026-08-14 | ROSSI DINO A | director | Gift | 3,691 | 75,000 | Form 4 |
| 2026-06-25 | Thomas John Charles | officer | Option exercise | 1,000 | 1,000 | Form 4 |
| 2026-06-25 | Thomas John Charles | officer | Option exercise | 1,000 | 6,500 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Withheld for tax | 11,942 | 1,497,133 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Withheld for tax | 11,942 | 1,497,133 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Withheld for tax | 10,236 | 1,425,975 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Withheld for tax | 10,236 | 1,425,975 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Withheld for tax | 3,981 | 1,482,825 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Withheld for tax | 3,981 | 1,482,825 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Withheld for tax | 3,262 | 22,806 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Withheld for tax | 2,605 | 1,500,253 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Withheld for tax | 2,605 | 1,500,253 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Withheld for tax | 1,820 | 1,428,155 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Withheld for tax | 1,820 | 1,428,155 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Withheld for tax | 240 | 23,116 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 8,750 | 17,500 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 4,000 | 1,429,975 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 22,500 | 1,436,211 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 5,725 | 1,502,858 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 26,250 | 1,509,075 | Form 4 |
| 2026-02-27 | Krishnan Krish S | director | Option exercise | 8,750 | 1,486,806 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Award / grant | 5,442 | 5,442 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Option exercise | 550 | 1,650 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Option exercise | 7,500 | 0 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Option exercise | 550 | 23,356 | Form 4 |
| 2026-02-27 | ROMANO KATHRYN | officer | Award / grant | 13,575 | 13,575 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Option exercise | 22,500 | 0 | Form 4 |
| 2026-02-27 | Krishnan Suma | director | Option exercise | 4,000 | 12,000 | Form 4 |
Source: SEC Form 4 filings. Each row links to its original filing.
Across 2012–2021, stocks where a CEO, C-suite officer, or director had recently made an open-market common-stock purchase ran about +28 bp per month above the universe average (n=34,268 stock-weeks). A historical tendency, not a prediction.
Congressional disclosures
No congressional trades disclosed for this company.
Research tool, not investment advice — historical frequencies, not recommendations. A product of Marovel Technologies LLC. Full terms.